Application of tunable resistive pulse sensing for the quantification of submicron particles in pharmaceutical monoclonal antibody preparations

Application of tunable resistive pulse sensing for the quantification of submicron particles in pharmaceutical monoclonal antibody preparations

Posted on by Cody

Tunable resistive pulse sensing (TRPS, qNano Gold, IZON Ltd.) was investigated as a way to quantify submicron particles (SMPs) between 0.1 and 1 µm in options of biopharmaceuticals. To cut back pattern dilution, a spiking-in method was used so as to add the applicable quantity of electrolytes required for the measurement. For right particle quantification, an electrolyte focus of at the very least 50 mM sodium chloride was wanted. Intra- and inter-nanopore variability had been beneath 5% for measurement and beneath 10% for focus measurements when analyzing polystyrene normal beads.

Submicron particle counts in a stir pressured IgG1 monoclonal antibody formulation resulted in a non-symmetrical, nearly bell-shaped measurement distribution with a most at 250 nm when utilizing a NP300 nanopore (IZON Ltd.). It was proven that particle counts are closely underestimated beneath 250 nm, and due to this fact it’s endorsed to quantify particle counts by TRPS in samples with heterogeneous particle measurement distributions (e.g., biopharmaceuticals) solely ranging from the most of the histogram in the direction of the higher restrict of detection.

Extremely drug-resistant (XDR) Acinetobacter baumannii is a infamous and ceaselessly encountered pathogen demanding novel therapeutic interventions. An preliminary monoclonal antibody (MAb), C8, raised in opposition to A. baumannii capsule proved a extremely efficient remedy in opposition to a minority of medical isolates. To overcome this limitation, we broadened protection by creating a second antibody for use in a mix routine.

Retrospective immunohistochemical investigation on dolphin morbillivirus an infection by evaluating the efficiency of heterologous monoclonal and polyclonal antibodies – Short communication

Dolphin morbillivirus (DMV) is a pathogen of nice concern in free-ranging cetaceans. Confirmation and staging of morbillivirus infections depend on histology and immunohistochemistry (IHC), following molecular detection. As at the current time no particular antibodies (Abs) in opposition to DMV can be found, two heterologous Abs have been used worldwide for the examinations of morbillivirus infections of cetaceans. One is a monoclonal Ab (MoAb) ready in opposition to the N protein of canine distemper virus (CDV), whereas the different is a polyclonal Ab raised in rabbits in opposition to rinderpest virus (RPV).

Both Abs are recognized to point out cross-reactivity with DMV. In this examine we in contrast the labelling high quality and the neuroanatomical distribution of staining with these two Abs by means of IHC evaluation. To this finish, serial sections of the goal organs from ten free-ranging stranded cetaceans, beforehand recognized as being contaminated with DMV by PCR and/or serology, had been subjected to IHC. The mind, lungs and lymph nodes of one animal had been discovered to be constructive with each Abs. From two different animals, the mind and the spleen, respectively, examined constructive solely with the polyclonal Ab. In the constructive mind tissues, multifocal immunostaining was noticed, with comparable staining location and extent, with the two antibodies examined.

Application of tunable resistive pulse sensing for the quantification of submicron particles in pharmaceutical monoclonal antibody preparations

Our outcomes counsel that the polyclonal anti-RPV Ab may need a stronger binding exercise to DMV than the anti-CDV MoAb. Nevertheless, the elaboration and use of particular anti-DMV Abs is perhaps important to ensure conclusive outcomes in diagnostic and pathogenetic investigations. We report the isolation of two human IgG1k monoclonal antibodies (mAbs) directed in opposition to the SARS-CoV-2 spike protein. These mAbs had been remoted from two donors who had recovered from COVID-19 an infection throughout the first pandemic peak in the Lombardy area of Italy, the first European and initially most affected area in March 2020.

We used the technique of EBV immortalization of purified reminiscence B cells and supernatant screening with a spike S1/2 assay for mAb isolation. This technique allowed fast isolation of clones, with one donor exhibiting about 7% of clones constructive in opposition to spike protein, whereas the different donor didn’t produce constructive clones out of 91 examined. RNA was extracted from constructive clones 39-47 days post-EBV an infection, permitting VH and VL sequencing. The identical clones had been sequenced once more after an extra 100 days in tradition, exhibiting that no mutation had taken place throughout in vitro growth.

Effects of Mild and Moderate Monoclonal Antibody Dose on Inflammation, Bone Loss, and Activation of the Central Nervous System in a Female Collagen Antibody-induced Arthritis Mouse Model

Induction of extreme inflammatory arthritis in the collagen antibody-induced arthritis (CAIA) murine mannequin causes in depth joint injury and pain-like habits compromising evaluation. While delicate fashions are much less extreme, their diminished, variable penetrance makes evaluation of remedy efficacy troublesome. This examine aimed to check macroscopic and microscopic modifications in the paws, together with central nervous system activation between a light and average CAIA mannequin. Balb/c mice (n=18) had been allotted to regulate, delicate, and average CAIA teams.

Recombinant Angiotensinogen (AGT)
4-RPA797Ra01
  • EUR 413.60
  • EUR 214.00
  • EUR 1276.00
  • EUR 492.00
  • EUR 884.00
  • EUR 340.00
  • EUR 3040.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
  • Uniprot ID: P01015
  • Buffer composition: PBS, pH 7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
  • Form: Freeze-dried powder
  • Predicted Molecular Mass (KD): 55.3kDa
  • Isoelectric Point: 5.4
Description: Recombinant Rat Angiotensinogen expressed in: E.coli

Recombinant Human Angiotensinogen Protein
RP01021 5 μg
EUR 183

Angiotensinogen antibody
70R-12752 100 ul
EUR 457
Description: Affinity purified Rabbit polyclonal Angiotensinogen antibody

Angiotensinogen antibody
70R-13411 100 ul
EUR 457
Description: Affinity purified Rabbit polyclonal Angiotensinogen antibody

Angiotensinogen antibody
10R-A130a 200 ul
EUR 565
Description: Mouse monoclonal Angiotensinogen antibody

Angiotensinogen antibody
10R-A131a 200 ul
EUR 457
Description: Mouse monoclonal Angiotensinogen antibody

Angiotensinogen Antibody
49159-100ul 100ul
EUR 333

Angiotensinogen Antibody
49159-50ul 50ul
EUR 239

Angiotensinogen Peptide
20-abx265209
  • EUR 565.00
  • EUR 954.00
  • EUR 398.00
  • 10 mg
  • 25 mg
  • 5 mg
  • Shipped within 5-10 working days.

Angiotensinogen Peptide
20-abx265535
  • EUR 551.00
  • EUR 926.00
  • EUR 398.00
  • 10 mg
  • 25 mg
  • 5 mg
  • Shipped within 5-10 working days.

Angiotensinogen Peptide
20-abx266414
  • EUR 523.00
  • EUR 871.00
  • EUR 384.00
  • 10 mg
  • 25 mg
  • 5 mg
  • Shipped within 5-10 working days.

Angiotensinogen Peptide
20-abx266467
  • EUR 551.00
  • EUR 926.00
  • EUR 398.00
  • 10 mg
  • 25 mg
  • 5 mg
  • Shipped within 5-10 working days.

Angiotensinogen Rabbit mAb
A11689-100ul 100 ul
EUR 410

Angiotensinogen Rabbit mAb
A11689-200ul 200 ul
EUR 571

Angiotensinogen Rabbit mAb
A11689-20ul 20 ul
EUR 221

Angiotensinogen Rabbit mAb
A11689-50ul 50 ul
EUR 287

Human Angiotensinogen Antibody
11013-05011 150 ug
EUR 217

Angiotensinogen (1- 13)
5-00696 4 x 5mg Ask for price

Human Angiotensinogen (AGT)
1-CSB-EP001463HU1
  • EUR 380.00
  • EUR 214.00
  • EUR 1309.00
  • EUR 560.00
  • EUR 873.00
  • EUR 262.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
  • MW: 57.9 kDa
  • Buffer composition: Tris-based buffer with 50% glycerol.
Description: Recombinant Human Angiotensinogen(AGT),partial expressed in E.coli

Angiotensinogen, Human Plasma
ATN15-N-100 100 ug
EUR 225

Angiotensinogen (AGT) Antibody
abx010360-100ul 100 ul
EUR 411
  • Shipped within 5-10 working days.

Angiotensinogen (AGT) Antibody
20-abx004798
  • EUR 411.00
  • EUR 592.00
  • EUR 182.00
  • EUR 314.00
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul
  • Shipped within 5-10 working days.

Angiotensinogen (AGT) Antibody
20-abx214416
  • EUR 411.00
  • EUR 300.00
  • 100 ul
  • 50 ul
  • Shipped within 5-10 working days.

Angiotensinogen (AGT) Antibody
20-abx175400
  • EUR 1135.00
  • EUR 551.00
  • 1 mg
  • 200 ug
  • Please enquire.

Angiotensinogen (AGT) Antibody
20-abx211344
  • EUR 411.00
  • EUR 300.00
  • 100 ul
  • 50 ul
  • Shipped within 5-10 working days.

Angiotensinogen (AGT) Antibody
20-abx101137
  • EUR 398.00
  • EUR 133.00
  • EUR 1107.00
  • EUR 537.00
  • EUR 314.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-12 working days.

Angiotensinogen (AGT) Antibody
20-abx101138
  • EUR 411.00
  • EUR 133.00
  • EUR 1135.00
  • EUR 551.00
  • EUR 314.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-12 working days.

Angiotensinogen (AGT) Antibody
20-abx101139
  • EUR 425.00
  • EUR 133.00
  • EUR 1177.00
  • EUR 578.00
  • EUR 328.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-12 working days.

Angiotensinogen (AGT) Antibody
20-abx101140
  • EUR 328.00
  • EUR 815.00
  • EUR 425.00
  • EUR 154.00
  • EUR 258.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-7 working days.

Angiotensinogen (AGT) Antibody
20-abx110982
  • EUR 732.00
  • EUR 398.00
  • 150 ul
  • 50 ul
  • Shipped within 5-10 working days.

Angiotensinogen (AGT) Antibody
20-abx128540
  • EUR 398.00
  • EUR 133.00
  • EUR 1107.00
  • EUR 537.00
  • EUR 314.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-12 working days.

Angiotensinogen (AGT) Antibody
20-abx171240
  • EUR 787.00
  • EUR 411.00
  • 1 mg
  • 200 ug
  • Please enquire.

Angiotensinogen (AGT) Antibody
abx033720-400ul 400 ul
EUR 523
  • Shipped within 5-10 working days.

Angiotensinogen (AGT) Antibody
abx033720-80l 80 µl
EUR 286
  • Shipped within 5-10 working days.

Angiotensinogen (AGT) Antibody
abx033721-400ul 400 ul
EUR 523
  • Shipped within 5-10 working days.

Angiotensinogen (AGT) Antibody
abx033721-80l 80 µl
EUR 286
  • Shipped within 5-10 working days.

Angiotensinogen (AGT) Antibody
20-abx241726
  • EUR 411.00
  • EUR 300.00
  • 100 ul
  • 50 ul
  • Shipped within 5-10 working days.

Angiotensinogen (AGT) Antibody
20-abx241946
  • EUR 411.00
  • EUR 300.00
  • 100 ul
  • 50 ul
  • Shipped within 5-10 working days.

Angiotensinogen (AGT) Antibody
20-abx241947
  • EUR 411.00
  • EUR 300.00
  • 100 ul
  • 50 ul
  • Shipped within 5-10 working days.

Angiotensinogen (AGT) Antibody
20-abx242324
  • EUR 411.00
  • EUR 300.00
  • 100 ul
  • 50 ul
  • Shipped within 5-10 working days.

Angiotensinogen Conjugated Antibody
C49159 100ul
EUR 397

Angiotensinogen (AGT) Antibody
20-abx339646
  • EUR 411.00
  • EUR 300.00
  • 100 ul
  • 50 ul
  • Shipped within 5-10 working days.

Angiotensinogen (AGT) Antibody
20-abx320213
  • EUR 300.00
  • EUR 244.00
  • 100 ul
  • 50 ul
  • Shipped within 5-10 working days.

Angiotensinogen (AGT) Antibody
20-abx322250
  • EUR 300.00
  • EUR 244.00
  • 100 ul
  • 50 ul
  • Shipped within 5-10 working days.

Angiotensinogen (AGT) Antibody
20-abx301357
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

Angiotensinogen (AGT) Antibody
abx230393-100ug 100 ug
EUR 509
  • Shipped within 5-12 working days.

Angiotensinogen (AGT) Antibody
abx230394-100ug 100 ug
EUR 481
  • Shipped within 5-12 working days.

Angiotensinogen (AGT) Antibody
abx230395-100ug 100 ug
EUR 481
  • Shipped within 5-12 working days.

Eukaryotic Angiotensinogen (AGT)
4-EPA797Mu61
  • EUR 466.46
  • EUR 228.00
  • EUR 1474.24
  • EUR 558.08
  • EUR 1016.16
  • EUR 375.00
  • EUR 3535.60
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
  • Uniprot ID: P11859
  • Buffer composition: 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.
  • Form: Freeze-dried powder
  • Predicted Molecular Mass (KD): 51.2kDa
  • Isoelectric Point: 5.0
Description: Recombinant Mouse Angiotensinogen expressed in: 293F cell

Eukaryotic Angiotensinogen (AGT)
4-EPA797Ra61
  • EUR 471.84
  • EUR 229.00
  • EUR 1494.40
  • EUR 564.80
  • EUR 1029.60
  • EUR 379.00
  • EUR 3586.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
  • Uniprot ID: P01015
  • Buffer composition: 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 5% Trehalose and Proclin300.
  • Form: Freeze-dried powder
  • Predicted Molecular Mass (KD): 51.2kDa
  • Isoelectric Point: 5.3
Description: Recombinant Rat Angiotensinogen expressed in: 293F cell

anti- Angiotensinogen antibody
FNab00393 100µg
EUR 548.75
  • Recommended dilution: WB: 1:200-1:2000
  • IHC: 1:20-1:200
  • Immunogen: angiotensinogen(serpin peptidase inhibitor, clade A, member 8)
  • Uniprot ID: P01019
  • Gene ID: 183
  • Research Area: Cardiovascular, Metabolism
Description: Antibody raised against Angiotensinogen

anti- Angiotensinogen antibody
FNab00394 100µg
EUR 505.25
  • Recommended dilution: WB: 1:500-1:5000
  • IHC: 1:20-1:200
  • IF: 1:10-1:100
  • Immunogen: angiotensinogen(serpin peptidase inhibitor, clade A, member 8)
  • Uniprot ID: P01019
  • Gene ID: 183
  • Research Area: Cardiovascular, Metabolism
Description: Antibody raised against Angiotensinogen

anti- Angiotensinogen antibody
FNab00395 100µg
EUR 505.25
  • Recommended dilution: WB: 1:500-1:5000
  • IHC: 1:20-1:200
  • Immunogen: angiotensinogen(serpin peptidase inhibitor, clade A, member 8)
  • Uniprot ID: P01019
  • Gene ID: 183
  • Research Area: Cardiovascular, Metabolism
Description: Antibody raised against Angiotensinogen

Anti-Angiotensinogen antibody
PAab00393 100 ug
EUR 386

Anti-Angiotensinogen antibody
PAab00394 100 ug
EUR 355

Angiotensinogen (1-14), human
5-00697 4 x 5mg Ask for price

Angiotensinogen (1-14), Porcine
5-00698 4 x 5mg Ask for price

Angiotensinogen (1-14) , Rat
5-00699 4 x 5mg Ask for price

Rat angiotensinogen ELISA kit
55R-2262 1 kit
EUR 1373
Description: Rat angiotensinogen ELISA kit for use in research

Mouse Angiotensinogen ELISA kit
E03A0497-192T 192 tests
EUR 1270
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
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Description: A competitive ELISA for quantitative measurement of Mouse Angiotensinogen in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Angiotensinogen ELISA kit
E03A0497-48 1 plate of 48 wells
EUR 520
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Mouse Angiotensinogen in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Angiotensinogen ELISA kit
E03A0497-96 1 plate of 96 wells
EUR 685
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Mouse Angiotensinogen in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Angiotensinogen ELISA kit
E04A0497-192T 192 tests
EUR 1270
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Rabbit Angiotensinogen in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Angiotensinogen ELISA kit
E04A0497-48 1 plate of 48 wells
EUR 520
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Rabbit Angiotensinogen in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Angiotensinogen ELISA kit
E04A0497-96 1 plate of 96 wells
EUR 685
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
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Description: A competitive ELISA for quantitative measurement of Rabbit Angiotensinogen in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Angiotensinogen ELISA kit
E02A0497-192T 192 tests
EUR 1270
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Rat Angiotensinogen in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Angiotensinogen ELISA kit
E02A0497-48 1 plate of 48 wells
EUR 520
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Rat Angiotensinogen in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Angiotensinogen ELISA kit
E02A0497-96 1 plate of 96 wells
EUR 685
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
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Description: A competitive ELISA for quantitative measurement of Rat Angiotensinogen in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Angiotensinogen ELISA kit
E06A0497-192T 192 tests
EUR 1270
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
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Description: A competitive ELISA for quantitative measurement of Goat Angiotensinogen in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Angiotensinogen ELISA kit
E06A0497-48 1 plate of 48 wells
EUR 520
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
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Description: A competitive ELISA for quantitative measurement of Goat Angiotensinogen in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Angiotensinogen ELISA kit
E06A0497-96 1 plate of 96 wells
EUR 685
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
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Description: A competitive ELISA for quantitative measurement of Goat Angiotensinogen in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Angiotensinogen ELISA kit
E01A0497-192T 192 tests
EUR 1270
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
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Description: A competitive ELISA for quantitative measurement of Human Angiotensinogen in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Angiotensinogen ELISA kit
E01A0497-48 1 plate of 48 wells
EUR 520
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Human Angiotensinogen in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Angiotensinogen ELISA kit
E01A0497-96 1 plate of 96 wells
EUR 685
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive ELISA for quantitative measurement of Human Angiotensinogen in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Anti-Angiotensinogen/AGT Antibody
A02103-1 100ug/vial
EUR 334

Human Angiotensinogen (AGT) Protein
20-abx065351
  • EUR 746.00
  • EUR 300.00
  • EUR 2332.00
  • EUR 885.00
  • EUR 523.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-7 working days.

Mouse Angiotensinogen (AGT) Protein
20-abx065352
  • EUR 578.00
  • EUR 258.00
  • EUR 1720.00
  • EUR 690.00
  • EUR 425.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-7 working days.

Rat Angiotensinogen (AGT) Protein
20-abx065353
  • EUR 578.00
  • EUR 258.00
  • EUR 1720.00
  • EUR 690.00
  • EUR 425.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-12 working days.

Human Angiotensinogen (AGT) Protein
20-abx065354
  • EUR 746.00
  • EUR 300.00
  • EUR 2332.00
  • EUR 885.00
  • EUR 523.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-12 working days.

Monkey Angiotensinogen ELISA kit
E09A0497-192T 192 tests
EUR 1270
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
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Description: A competitive ELISA for quantitative measurement of Monkey Angiotensinogen in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Angiotensinogen ELISA kit
E09A0497-48 1 plate of 48 wells
EUR 520
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
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Description: A competitive ELISA for quantitative measurement of Monkey Angiotensinogen in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Angiotensinogen ELISA kit
E09A0497-96 1 plate of 96 wells
EUR 685
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
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Description: A competitive ELISA for quantitative measurement of Monkey Angiotensinogen in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Angiotensinogen ELISA kit
E08A0497-192T 192 tests
EUR 1270
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
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Description: A competitive ELISA for quantitative measurement of Canine Angiotensinogen in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Angiotensinogen ELISA kit
E08A0497-48 1 plate of 48 wells
EUR 520
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
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Description: A competitive ELISA for quantitative measurement of Canine Angiotensinogen in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Angiotensinogen ELISA kit
E08A0497-96 1 plate of 96 wells
EUR 685
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
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Description: A competitive ELISA for quantitative measurement of Canine Angiotensinogen in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Angiotensinogen ELISA kit
E07A0497-192T 192 tests
EUR 1270
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
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Description: A competitive ELISA for quantitative measurement of Porcine Angiotensinogen in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Angiotensinogen ELISA kit
E07A0497-48 1 plate of 48 wells
EUR 520
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
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Description: A competitive ELISA for quantitative measurement of Porcine Angiotensinogen in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Angiotensinogen ELISA kit
E07A0497-96 1 plate of 96 wells
EUR 685
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
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Description: A competitive ELISA for quantitative measurement of Porcine Angiotensinogen in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Angiotensinogen (AGT) Antibody (Biotin)
20-abx272741
  • EUR 425.00
  • EUR 230.00
  • EUR 1219.00
  • EUR 592.00
  • EUR 328.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-15 working days.

Angiotensinogen (AGT) Antibody (Biotin)
20-abx273211
  • EUR 453.00
  • EUR 244.00
  • EUR 1288.00
  • EUR 620.00
  • EUR 342.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-15 working days.

Angiotensinogen (AGT) Antibody Pair
20-abx370425
  • EUR 1595.00
  • EUR 1024.00
  • 10 × 96 tests
  • 5 × 96 tests
  • Shipped within 5-15 working days.

Angiotensinogen (AGT) Antibody Pair
20-abx370604
  • EUR 1706.00
  • EUR 1094.00
  • 10 × 96 tests
  • 5 × 96 tests
  • Shipped within 5-15 working days.

Mouse Angiotensinogen (AGT) Protein
20-abx651467
  • EUR 648.00
  • EUR 272.00
  • EUR 1984.00
  • EUR 773.00
  • EUR 467.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-7 working days.

Rat Angiotensinogen (AGT) Protein
20-abx651468
  • EUR 662.00
  • EUR 272.00
  • EUR 2012.00
  • EUR 787.00
  • EUR 481.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-7 working days.

Angiotensinogen (AGT) Antibody (FITC)
20-abx273972
  • EUR 453.00
  • EUR 244.00
  • EUR 1316.00
  • EUR 634.00
  • EUR 342.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-15 working days.

Angiotensinogen (AGT) Antibody (FITC)
20-abx274115
  • EUR 467.00
  • EUR 244.00
  • EUR 1386.00
  • EUR 648.00
  • EUR 356.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-15 working days.

Paw irritation, bone quantity (BV), and paw quantity (PV) had been assessed. Histologically, the entrance paws had been assessed for joint irritation, cartilage injury, and pre/osteoclast-like cells and the lumbar spinal wire and the periaqueductal grey (PAG) area of the mind for glial reactivity. A average CAIA dose induced (1) considerably larger native paw irritation, inflammatory cell infiltration, and PV; (2) considerably extra osteoclast-like cells on the bone floor and inside the surrounding comfortable tissue; and (3) considerably larger glial reactivity inside the PAG in contrast with the delicate CAIA mannequin. These findings assist the use of a average CAIA mannequin (increased dose of monoclonal antibodies with low-dose lipopolysaccharide) to induce extra constant histopathological options, with out extreme joint destruction.

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