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Preferential Light-Chain Labeling of Native Monoclonal Antibodies Improves the Properties of Fluorophore Conjugates

Preferential Light-Chain Labeling of Native Monoclonal Antibodies Improves the Properties of Fluorophore Conjugates

Posted on September 3, 2021September 4, 2021 by Cody

Site particular labeling strategies have important potential to boost the properties of antibody conjugates. While studied extensively in the context of antibody-drug conjugates (ADCs), few research have examined the influence of homogenous labeling on the properties of antibody-fluorophore conjugates (AFCs). We report the utility of pentafluorophenyl (PFP) esters, which had beforehand been proven to be fairly selective for Ok188 of the kappa gentle chain of human IGG antibodies, towards producing AFCs. We present that easy substitute of N-hydroxy succinimide (NHS) with PFP dramatically will increase the light-chain specificity of near-infrared (NIR) AFCs. Comparing the properties of AFCs labeled utilizing NHS and PFP-activated esters reveals that the latter displays lowered aggregation and improved brightness, each in vitro and in vivo.

Overall, the use of PFP esters gives a remarkably easy strategy to offer selectively labeled antibodies with improved properties. Fully automated characterization of monoclonal antibody (mAb) cost variants utilizing four-dimensional liquid chromatography-mass spectrometry (4D-LC-MS) is reported and illustrated. Charge variants resolved by cation-exchange chromatography (CEX) utilizing a salt- or pH-gradient are collected in loops put in on a a number of heart-cutting valve and consequently subjected to on-line desalting, denaturation, discount and trypsin digestion previous to LC-MS primarily based peptide mapping.

This innovation which considerably reduces turnaround time, pattern manipulation, loss and artefacts and will increase data gathering, is described in nice technical element, and utilized to characterize the cost heterogeneity related to three therapeutic mAbs. Sequence coverages > 95% are obtained for main and minor cost variants (> 1.0%). Post-translational modifications (PTMs) and modification websites are readily revealed in a repeatable method together with unstable succinimide intermediates which aren’t maintained when performing classical in-solution in a single day digestion of offline collected CEX peaks.

A chondroitin sulfate proteoglycan 4‑particular monoclonal antibody inhibits melanoma cell invasion in a spheroid mannequin

The overexpression of chondroitin sulfate proteoglycan 4 (CSPG4) is related to a number of tumor sorts, together with malignant melanoma, squamous cell carcinoma, triple‑unfavorable breast carcinoma, oligodendrocytomas or gliomas. Due to its restricted distribution in regular tissues, CSPG4 has been thought-about a possible goal for a number of antitumor approaches, together with monoclonal antibody (mAb) therapies. The intention of the current examine was to characterize the influence of the CSPG4‑particular mAb clone 9.2.27 by itself or together with the generally used BRAF‑selective inhibitor, PLX4032, on completely different capabilities of melanoma cells to evaluate the potential synergistic results.

The BRAF V600‑mutant human melanoma cell strains, M14 (CSPG4‑unfavorable) and WM164 (CSPG4‑optimistic), have been uncovered to the CSPG4‑particular 9.2.27 mAb and/or PLX4032. Cell viability and colony formation capability have been evaluated. A 3D‑cell tradition spheroid mannequin was used to evaluate the invasive properties of the handled cells. In addition, stream cytometric evaluation of apoptosis and cell cycle analyses have been carried out. Incubation of the WM164 cell line with CSPG4‑particular 9.2.27 mAb decreased viability, colony formation skill and the invasive capability of CSPG4‑optimistic tumor cells, which was not the case for the CSPG4‑unfavorable M14 cell line. Combined therapy of the WM164 cells with 9.2.27 mAb plus PLX4032 didn’t exert any important further impact compared to therapy with PLX4032 alone in the clonogenic and invasion assays.

Preferential Light-Chain Labeling of Native Monoclonal Antibodies Improves the Properties of Fluorophore Conjugates

M14 cell cycle distribution was not influenced by the CSPG4‑particular 9.2.27 mAb. By distinction, the publicity of WM164 cells to the mAb resulted in an arrest of the cells in the S section. Moreover, mixed therapy of the WM164 cells led to a considerably elevated accumulation of cells in the subG1 section, mixed with a lower of cells in the G2/M section. On the entire, findings of the current examine point out that the CSPG4‑particular 9.2.27 mAb exerts an anti‑invasive impact on CSPG4‑optimistic melanoma spheroids, which isn’t enhanced by BRAF inhibition. These findings present the foundation for additional investigations on the results of anti‑CSPG4‑primarily based therapies of CSPG4‑optimistic tumors.

Pathogenic Role of Circulating Citrullinated Antigens and Anti-Cyclic Monoclonal Citrullinated Peptide Antibodies in Rheumatoid Arthritis

We examined whether or not it’s potential to immediately detect citrullinated antigens in the serum of rheumatoid arthritis (RA) sufferers utilizing a monoclonal antibody (mAb) designed to be particular for citrullinated peptides. In order to verify the potential of the mAb as a direct arthritis-inducing substance by experimental mannequin of RA, a monoclonal antibody (mAb) 12G1 was generated utilizing by immunization of mice with a difficult cyclic citrullinated peptide. Immunohistochemical evaluation of RA-affected synovial tissue confirmed that our mAb 12G1 may certainly detect citrullinated proteins in goal tissues.

Subsequently, serum ranges of citrullinated sort II collagen and filaggrin have been measured in wholesome volunteers, sufferers with RA, ankylosing spondylitis (AS), and systemic lupus erythematosus (SLE) utilizing a 12G1-based sandwich ELISA. This confirmed that citrullinated filaggrin confirmed 78.9% sensitivity and 85.9% specificity for RA analysis with a cutoff optical density (OD) worth of 1.013, comparable with the outcomes from a second-generation anti-citrullinated protein antibody (ACPA) check. Circulating citrullinated collagen and filaggrin have been detected even in sera of RA sufferers who have been unfavorable for each rheumatoid issue (RF) and ACPA.

Donkey anti Goat IgG (H + L) (Alexa Fluor 594)

43R-ID005AF Fitzgerald 500 ug
EUR 338
Description: Donkey anti Goat IgG (H + L) secondary antibody (Alexa Fluor 594)

Donkey Anti-Goat IgG (H+L), Alexa Fluor® 594 Conjugated

Ab8011-001 GenDepot 1mg
EUR 334

Goat Anti-Rabbit IgG(H+L) Alexa Fluor 647–conjugated

S0013 Affbiotech 200ul
EUR 304

Goat Anti-Rabbit IgG(H+L) Alexa Fluor 488–conjugated

S0018 Affbiotech 200ul
EUR 304

Donkey anti Goat IgG (H + L) (Fab 2) (Alexa Fluor 594)

43R-ID012AF Fitzgerald 300 ug
EUR 410
Description: Donkey anti Goat IgG (H + L) secondary antibody (Fab'2) (Alexa Fluor 594)

Donkey anti Rat IgG (H + L) (Alexa Fluor 594)

43R-ID022AF Fitzgerald 500 ug
EUR 364
Description: Donkey anti Rat IgG (H + L) secondary antibody (Alexa Fluor 594)

Donkey anti Rat IgG (H + L) (Alexa Fluor 594)

43R-ID047AF Fitzgerald 500 ug
EUR 462
Description: Donkey anti Rat IgG (H + L) secondary antibody (Alexa Fluor 594)

Goat Anti-Mouse IgG(H+L) Alexa Fluor 647–conjugated

S0014 Affbiotech 200ul
EUR 304

Goat Anti-Mouse IgG(H+L) Alexa Fluor 488–conjugated

S0017 Affbiotech 200ul
EUR 304

Rabbit anti Chicken IgY (H + L) (Alexa Fluor 594)

43R-IR016AF Fitzgerald 1 mg
EUR 281
Description: Rabbit anti Chicken IgY (H + L) secondary antibody (Alexa Fluor 594)

Rabbit Anti-Rat IgG (H+L)-Alexa 594 Fluor conjugate (adsorbed with human IgG)

50337 Alpha Diagnostics 0.5 ml
EUR 225

Donkey anti Goat IgG (H + L) (Alexa Fluor 647)

43R-ID028AF Fitzgerald 500 ug
EUR 430
Description: Donkey anti Goat IgG (H + L) secondary antibody (Alexa Fluor 647)

Donkey Anti-Rabbit IgG (H+L), Alexa Fluor® 488 Conjugated

Ab8032-001 GenDepot 0.5mg
EUR 435

Goat anti Mouse IgG1 (Alexa Fluor 488)

43R-1649 Fitzgerald 500 ug
EUR 570
Description: Goat anti Mouse IgG1 secondary antibody (Alexa Fluor 488)

Donkey anti Chicken IgY (H + L) (Alexa Fluor 594)

43R-ID056AF Fitzgerald 500 ug
EUR 343
Description: Donkey anti Chicken IgY secondary antibody (H + L) (Alexa Fluor 594)

AF594-streptavidin conjugate [Streptavidin, Alexa Fluor™ 594 Conjugate]

16892 AAT Bioquest 1 mg
EUR 176

AF594 Phalloidin [equivalent to Alexa Fluor® 594 phalloidin]

23158 AAT Bioquest 300 Tests
EUR 306

Anti-RPSA Alexa Fluor® 488

A4-829-C100 ExBio 0.1 mg
EUR 310

Anti-CD40 antibody (Alexa-fluor 488)

STJ170000 St John's Laboratory 100 µg
EUR 393
Description: CD40 (48 to 50 kDa) is a transmembrane glycoprotein mainly expressed on the surface of B cells and also expressed on monocytes, dendritic cells, and thymic epithelium. CD40 is a member of the tumor necrosis factor (TNF) receptor superfamily, which includes the low affinity nerve growth factor (NGF) receptor and CD95/Fas. CD40 is the receptor for CD40 ligand. CD40L (CD40L, CD154, gp39, and TRAM) belongs to the TNF gene family and is expressed more widely than CD40, predominantly on activated CD4+ T cells. Following interaction with CD40 ligand, CD40 mediates a number of major immunoregulatory functions, central to the control of thymus dependent humoral immunity and may be critical in the development of cell mediated immune responses. Other biological actions include B cell homotypic adhesion, proliferation, immunoglobulin isotype switch, and secretion. Activation of CD40 has also been shown to inhibit the growth of certain B cell lymphomas and to induce the death of transformed cells of mesenchymal or epithelial origin

Anti-LAMP3 antibody (Alexa-fluor 488)

STJ170004 St John's Laboratory 100 µg
EUR 393
Description: The dendritic cell lysosomal-associated membrane protein (DC-LAMP)/CD208 is a type I integral transmembrane glycoprotein mostly homologous to CD68, of about 45 kDa in mouse and 90 kDa in human (glycosylation), with a bipartite C-terminal structure divided by a serine/proline rich region, a transmembrane domain and a conserved tyrosine-based lysosomal targeting motif in its cytoplasmic tail. Initially cloned as a specific marker of human mature dendritic cells (DCs), DC-LAMP has been subsequently shown to be expressed in alveolar type II pneumocytes. In both cell types, the molecule is found in the limiting membrane of intracellular multi-lamellar bodies, known as MIIC (MHC class II compartments) in human mature DCs and as lung surfactant-containing lamellar bodies in type II pneumocytes. In the latter cell type, DC-LAMP expression is also detected at the cell surface.

Anti-LAMP3 antibody (Alexa-fluor 546)

STJ170005 St John's Laboratory 100 µg
EUR 393
Description: The dendritic cell lysosomal-associated membrane protein (DC-LAMP)/CD208 is a type I integral transmembrane glycoprotein mostly homologous to CD68, of about 45 kDa in mouse and 90 kDa in human (glycosylation), with a bipartite C-terminal structure divided by a serine/proline rich region, a transmembrane domain and a conserved tyrosine-based lysosomal targeting motif in its cytoplasmic tail. Initially cloned as a specific marker of human mature dendritic cells (DCs), DC-LAMP has been subsequently shown to be expressed in alveolar type II pneumocytes. In both cell types, the molecule is found in the limiting membrane of intracellular multi-lamellar bodies, known as MIIC (MHC class II compartments) in human mature DCs and as lung surfactant-containing lamellar bodies in type II pneumocytes. In the latter cell type, DC-LAMP expression is also detected at the cell surface.

Anti-LAMP3 antibody (Alexa-fluor 647)

STJ170006 St John's Laboratory 100 µg
EUR 393
Description: The dendritic cell lysosomal-associated membrane protein (DC-LAMP)/CD208 is a type I integral transmembrane glycoprotein mostly homologous to CD68, of about 45 kDa in mouse and 90 kDa in human (glycosylation), with a bipartite C-terminal structure divided by a serine/proline rich region, a transmembrane domain and a conserved tyrosine-based lysosomal targeting motif in its cytoplasmic tail. Initially cloned as a specific marker of human mature dendritic cells (DCs), DC-LAMP has been subsequently shown to be expressed in alveolar type II pneumocytes. In both cell types, the molecule is found in the limiting membrane of intracellular multi-lamellar bodies, known as MIIC (MHC class II compartments) in human mature DCs and as lung surfactant-containing lamellar bodies in type II pneumocytes. In the latter cell type, DC-LAMP expression is also detected at the cell surface.

Anti-IL3RA antibody (Alexa-fluor 488)

STJ170009 St John's Laboratory 100 µg
EUR 393
Description: IL3 exerts its biologic activity through its interaction with a cell surface receptor that consists of two subunits. The a subunit (CD123) specifically binds IL3, whereas the ß subunit is required for signaling and is common to the GMCSFR and IL5-R. 107D2.08 and 106C2.02 mAbs were obtained after mouse immunization with sorted human tonsillar PDC. Both clones strongly stain PDCs and basophils, weakly stain monocytes, CD34+ derived DCs and CD11c+ DC, while no staining is observed on T, B, NK cells as well as on mono-derived DCs. Staining with 107D2.08 and 106C2.02 mAbs are maintained on sorted PDC cultured in the presence of IL3 and CD40L, but lost when IL3 alone is added to the culture. The recognition of the IL3Ra chain by 107D2.08 and 106C2.02 was confirmed by transfection studies. 107D2.08 appeared to be the most appropriate clone for in situ studies. 107D2.08 allowed the first observation of IL3Ra+ cells in breast tumor microenvironment

Anti-IL3RA antibody (Alexa-fluor 546)

STJ170010 St John's Laboratory 100 µg
EUR 393
Description: IL3 exerts its biologic activity through its interaction with a cell surface receptor that consists of two subunits. The a subunit (CD123) specifically binds IL3, whereas the ß subunit is required for signaling and is common to the GMCSFR and IL5-R. 107D2.08 and 106C2.02 mAbs were obtained after mouse immunization with sorted human tonsillar PDC. Both clones strongly stain PDCs and basophils, weakly stain monocytes, CD34+ derived DCs and CD11c+ DC, while no staining is observed on T, B, NK cells as well as on mono-derived DCs. Staining with 107D2.08 and 106C2.02 mAbs are maintained on sorted PDC cultured in the presence of IL3 and CD40L, but lost when IL3 alone is added to the culture. The recognition of the IL3Ra chain by 107D2.08 and 106C2.02 was confirmed by transfection studies. 107D2.08 appeared to be the most appropriate clone for in situ studies. 107D2.08 allowed the first observation of IL3Ra+ cells in breast tumor microenvironment

Anti-IL3RA antibody (Alexa-fluor 647)

STJ170011 St John's Laboratory 100 µg
EUR 393
Description: IL3 exerts its biologic activity through its interaction with a cell surface receptor that consists of two subunits. The a subunit (CD123) specifically binds IL3, whereas the ß subunit is required for signaling and is common to the GMCSFR and IL5-R. 107D2.08 and 106C2.02 mAbs were obtained after mouse immunization with sorted human tonsillar PDC. Both clones strongly stain PDCs and basophils, weakly stain monocytes, CD34+ derived DCs and CD11c+ DC, while no staining is observed on T, B, NK cells as well as on mono-derived DCs. Staining with 107D2.08 and 106C2.02 mAbs are maintained on sorted PDC cultured in the presence of IL3 and CD40L, but lost when IL3 alone is added to the culture. The recognition of the IL3Ra chain by 107D2.08 and 106C2.02 was confirmed by transfection studies. 107D2.08 appeared to be the most appropriate clone for in situ studies. 107D2.08 allowed the first observation of IL3Ra+ cells in breast tumor microenvironment

Anti-CD207 antibody (Alexa-fluor 488)

STJ170014 St John's Laboratory 100 µg
EUR 393
Description: Langerin/CD207 is a transmembrane C-type lectin receptor (CLR) of epidermal and mucosal Langerhans cells (LCs) that induces Birbeck's granule formation. Langerin features a single carbohydrate recognition domain (CRD) with mannose-type specificity in its extracellular portion. Langerin is unique among the CLRs in that it contains an intracellular domain with a proline-rich motif. Langerin expression has not been reported outside the DC system. (Valladeau J et al, 1999, Eur.J.Immunol., 29:2695-2704; Valladeau J et al, 2000 Immunity, 12 : 71-81; Kashihara M et al, 1986, J.Invest.Derm., 87 :602-607 Ito T et al, 1999, J.Immunol., 163 :1409-1419 ;Saeland S & Valladeau J, CD207 (Langerin) Workshop reports 2002, Leukocyte-Typing VII, White Cell Diff Antigens, D. Mason et al, Eds, Oxford University Press:306-307)

Anti-CD207 antibody (Alexa-fluor 546)

STJ170015 St John's Laboratory 100 µg
EUR 393
Description: Langerin/CD207 is a transmembrane C-type lectin receptor (CLR) of epidermal and mucosal Langerhans cells (LCs) that induces Birbeck's granule formation. Langerin features a single carbohydrate recognition domain (CRD) with mannose-type specificity in its extracellular portion. Langerin is unique among the CLRs in that it contains an intracellular domain with a proline-rich motif. Langerin expression has not been reported outside the DC system. (Valladeau J et al, 1999, Eur.J.Immunol., 29:2695-2704; Valladeau J et al, 2000 Immunity, 12 : 71-81; Kashihara M et al, 1986, J.Invest.Derm., 87 :602-607 Ito T et al, 1999, J.Immunol., 163 :1409-1419 ;Saeland S & Valladeau J, CD207 (Langerin) Workshop reports 2002, Leukocyte-Typing VII, White Cell Diff Antigens, D. Mason et al, Eds, Oxford University Press:306-307)

Anti-CD207 antibody (Alexa-fluor 647)

STJ170016 St John's Laboratory 100 µg
EUR 393
Description: Langerin/CD207 is a transmembrane C-type lectin receptor (CLR) of epidermal and mucosal Langerhans cells (LCs) that induces Birbeck's granule formation. Langerin features a single carbohydrate recognition domain (CRD) with mannose-type specificity in its extracellular portion. Langerin is unique among the CLRs in that it contains an intracellular domain with a proline-rich motif. Langerin expression has not been reported outside the DC system. (Valladeau J et al, 1999, Eur.J.Immunol., 29:2695-2704; Valladeau J et al, 2000 Immunity, 12 : 71-81; Kashihara M et al, 1986, J.Invest.Derm., 87 :602-607 Ito T et al, 1999, J.Immunol., 163 :1409-1419 ;Saeland S & Valladeau J, CD207 (Langerin) Workshop reports 2002, Leukocyte-Typing VII, White Cell Diff Antigens, D. Mason et al, Eds, Oxford University Press:306-307)

Anti-IL7R antibody (Alexa-fluor 488)

STJ170020 St John's Laboratory 100 µg
EUR 393
Description: The IL7-R consists of 2 chains, IL-7R known as CD127 and common cytokine receptor chain known as CD132. A 75 to 80kDa human IL-7 receptor has been cloned that belongs to hematopoietic cytokinereceptor super family. R34-34, raised against human leukemic pre-B cells, recognized a molecule expressed on normal B cell precursors but not on mature B cells. This antibody specifically reverted IL-7 mediated growth inhibition of leukemic BCP (normal B cells precursors) and mature T cells. IL-7R expression is dramatically influenced by cytokines and antigens. This IL-7R displays both high and low affinity for its ligand (IL-7). Inhibitory and proliferative effects of IL-7 can be mediated through the same receptor on various lineages. CD4+ memory T cells express high level of IL-7R Subsets that express it generally require it, including progenitors of T and B cells, naïve and memory T cells. (Pandrau-Garcia D et al, 1994, Blood, 83, 3613-9 Mazzucchelli R et al, Nat. Review Immunol., 2007,7, 144-54)

Anti-IL7R antibody (Alexa-fluor 546)

STJ170021 St John's Laboratory 100 µg
EUR 393
Description: The IL7-R consists of 2 chains, IL-7R known as CD127 and common cytokine receptor chain known as CD132. A 75 to 80kDa human IL-7 receptor has been cloned that belongs to hematopoietic cytokinereceptor super family. R34-34, raised against human leukemic pre-B cells, recognized a molecule expressed on normal B cell precursors but not on mature B cells. This antibody specifically reverted IL-7 mediated growth inhibition of leukemic BCP (normal B cells precursors) and mature T cells. IL-7R expression is dramatically influenced by cytokines and antigens. This IL-7R displays both high and low affinity for its ligand (IL-7). Inhibitory and proliferative effects of IL-7 can be mediated through the same receptor on various lineages. CD4+ memory T cells express high level of IL-7R Subsets that express it generally require it, including progenitors of T and B cells, naïve and memory T cells. (Pandrau-Garcia D et al, 1994, Blood, 83, 3613-9 Mazzucchelli R et al, Nat. Review Immunol., 2007,7, 144-54)

Anti-IL7R antibody (Alexa-fluor 647)

STJ170022 St John's Laboratory 100 µg
EUR 393
Description: The IL7-R consists of 2 chains, IL-7R known as CD127 and common cytokine receptor chain known as CD132. A 75 to 80kDa human IL-7 receptor has been cloned that belongs to hematopoietic cytokinereceptor super family. R34-34, raised against human leukemic pre-B cells, recognized a molecule expressed on normal B cell precursors but not on mature B cells. This antibody specifically reverted IL-7 mediated growth inhibition of leukemic BCP (normal B cells precursors) and mature T cells. IL-7R expression is dramatically influenced by cytokines and antigens. This IL-7R displays both high and low affinity for its ligand (IL-7). Inhibitory and proliferative effects of IL-7 can be mediated through the same receptor on various lineages. CD4+ memory T cells express high level of IL-7R Subsets that express it generally require it, including progenitors of T and B cells, naïve and memory T cells. (Pandrau-Garcia D et al, 1994, Blood, 83, 3613-9 Mazzucchelli R et al, Nat. Review Immunol., 2007,7, 144-54)

Endoglin/CD105 Alexa Fluor

FC15024 Neuromics 100 Tests
EUR 448

Rabbit Anti-Rat IgG (H+L)-Alexa 488 Fluor conjugate (adsorbed with human IgG)

50336 Alpha Diagnostics 0.5 ml
EUR 225

DyLight®594 Conjugated Goat Anti-rabbit IgG (H+L)

BA1142-0.5 BosterBio 0.5ml
EUR 202

DyLight®594 Conjugated Goat Anti-rabbit IgG (H+L)

BA1142-1 BosterBio 1ml
EUR 334

Anti-Hu CD16 Alexa Fluor® 488

A4-646-T100 ExBio 100 tests
EUR 269

EGFR antibody (Alexa Fluor 488)

61R-E109BAF Fitzgerald 125 ug
EUR 706
Description: Mouse monoclonal EGFR antibody (Alexa Fluor 488)

SAM FCM (Alexa Fluor 647)

abx098902-100tests Abbexa 100 tests
EUR 1233

SAM FCM (Alexa Fluor 488)

abx098904-60tests Abbexa 60 tests
EUR 1358

iFluor™ 594 goat anti-rabbit IgG (H+L)

16628 AAT Bioquest 200 ug
EUR 115

iFluor™ 594 goat anti-rabbit IgG (H+L)

16806 AAT Bioquest 1 mg
EUR 176

Rabbit Anti-Goat IgG (H+L) Antibody (DyLight 594)

20-abx007407 Abbexa
  • EUR 272.00
  • EUR 453.00
  • 100 ul
  • 500 ul

Goat Anti-Rabbit IgG (H+L) Antibody (DyLight 594)

20-abx007433 Abbexa
  • EUR 272.00
  • EUR 453.00
  • 100 ul
  • 500 ul

DyLight®594 Conjugated Goat Anti-mouse IgG (H+L)

BA1141-0.5 BosterBio 0.5ml
EUR 202

DyLight®594 Conjugated Goat Anti-mouse IgG (H+L)

BA1141-1 BosterBio 1ml
EUR 334

Rabbit Polyclonal antibody Anti-CRBN

Anti-CRBN ImmunoStep 50 µg
EUR 349

Donkey anti Chicken IgY (H + L) (Alexa Fluor 647)

43R-ID060AF Fitzgerald 300 ug
EUR 425
Description: Donkey anti Chicken IgY (H + L) (Fab'2) (Alexa Fluor 647)

Anti-Hu CD72 Alexa Fluor® 488

A4-310-T100 ExBio 100 tests
EUR 269

Anti-Bov CD9 Alexa Fluor® 488

A4-354-C100 ExBio 0.1 mg
EUR 269

Anti-Hu CD30 Alexa Fluor® 700

A7-455-T100 ExBio 100 tests
EUR 269

Anti-Hu CD94 Alexa Fluor® 700

A7-727-T100 ExBio 100 tests
EUR 269

Anti-Hu CD56 Alexa Fluor® 700

A7-789-T100 ExBio 100 tests
EUR 269

Goat anti-Rabbit IgG SecondaryAntibody (peroxidase conjugated)

E0L3012-1 EnoGene 500ul
EUR 128

Goat anti-Rabbit IgG SecondaryAntibody (peroxidase conjugated)

E0L3012-2 EnoGene 1000ul
EUR 180

Rabbit anti Goat IgG

20-S5801R000-VO Fitzgerald 10 ml
EUR 133
Description: Rabbit anti Goat IgG antibody

Rabbit anti Goat IgG

40C-CB0536 Fitzgerald 1.5 mg
EUR 269
Description: Rabbit anti Goat IgG secondary antibody

Goat anti Rabbit IgG

40C-CB1157 Fitzgerald 5 mg
EUR 311
Description: Goat anti Rabbit IgG secondary antibody

Goat anti Rabbit IgG

41-GR30 Fitzgerald 10 mg
EUR 277
Description: Goat anti Rabbit IgG secondary antibody

Goat anti Rabbit IgG

41-GR31 Fitzgerald 5 mg
EUR 162
Description: Goat anti Rabbit IgG secondary antibody

Rabbit anti Goat IgG

41C-CB0529 Fitzgerald 2 mg
EUR 244
Description: Rabbit anti Goat IgG secondary antibody

Goat anti Rabbit IgG

41C-CB1143 Fitzgerald 2 mg
EUR 278
Description: Goat anti Rabbit IgG secondary antibody

Goat anti Rabbit IgG

41C-CB1150 Fitzgerald 10 mg
EUR 388
Description: Goat anti Rabbit IgG secondary antibody

Goat anti Rabbit IgG

41R-1079 Fitzgerald 2 mg
EUR 149
Description: Goat anti Rabbit IgG secondary antibody

Goat anti Rabbit IgG

40-GR30 Fitzgerald 100 ml
EUR 241
Description: Goat anti Rabbit IgG secondary antibody

Goat anti Rabbit IgG

40-GR30S Fitzgerald 100 ml
EUR 133
Description: Goat anti Rabbit IgG secondary antibody

Rabbit anti Goat IgG

E61I01002 EnoGene 1mg
EUR 343

goat Anti Rabbit IgG

E61I01301 EnoGene 1mg
EUR 274

iFluor™ 594 goat anti-rabbit IgG (H+L) *Cross Adsorbed*

16698 AAT Bioquest 200 ug
EUR 132

iFluor™ 594 goat anti-rabbit IgG (H+L) *Cross Adsorbed*

16833 AAT Bioquest 1 mg
EUR 219

Alpha Fluor™ 594 C5 Maleimide

1891 AAT Bioquest 1 mg
EUR 219

Streptavidin-Alexa594 (Alexas fluor 594) conjugate

SV-A594-100 Alpha Diagnostics 100 tests
EUR 225

Goat anti Rabbit IgG (H + L) (Agarose Conjugated)

43R-IG045AS Fitzgerald 20 mg
EUR 475
Description: Goat anti Rabbit IgG (H + L) secondary antibody (Agarose Conjugated)

Rabbit anti Goat IgG (H + L) (Agarose Conjugated)

43R-IR004AS Fitzgerald 20 mg
EUR 541
Description: Rabbit anti Goat IgG (H + L) secondary antibody (Agarose Conjugated)

Goat Anti-Rabbit IgG(H+L) FITC–conjugated

S0008 Affbiotech 200ul
EUR 376

Goat Anti-Rabbit IgG(H+L) CY3–conjugated

S0011 Affbiotech 200ul
EUR 304

Goat Anti-Rabbit IgG(H+L) TRITC–conjugated

S0015 Affbiotech 200ul
EUR 304

HRP-conjugated Goat Anti-Rabbit IgG Heavy Chain

AS063 Abclonal 100 ul
EUR 152

Goat anti- Rabbit IgG(H+L), Biotin Conjugated

E16SPB102-100 EnoGene 100Tests
EUR 343

Goat anti- Rabbit IgG(H+L), Biotin Conjugated

E16SPB102-1000 EnoGene 1000Tests
EUR 245

Goat anti- Rabbit IgG(H+L), Biotin Conjugated

E16SPB102-500 EnoGene 500Tests
EUR 167

Goat anti-Rabbit IgG(H+L), FITC Conjugated

E16SPF102-050 EnoGene 50Tests
EUR 239

Goat anti-Rabbit IgG(H+L), FITC Conjugated

E16SPF102-100 EnoGene 100Tests
EUR 343

Goat anti-Rabbit IgG(H+L), FITC Conjugated

E16SPF102-100U EnoGene 100μg
EUR 239

Goat anti-Rabbit IgG(H+L), FITC Conjugated

E16SPF102-500U EnoGene 500μg
EUR 343

Goat anti-Rabbit IgG(H+L), HRPO Conjugated

E16SPH102-100 EnoGene 100μl
EUR 239

Goat anti-Rabbit IgG(H+L), HRPO Conjugated

E16SPH102-1000 EnoGene 1000μl
EUR 434

Goat anti-Rabbit IgG(H+L), HRPO Conjugated

E16SPH102-500 EnoGene 500μl
EUR 343

Goat anti-Rabbit IgG(H+L), PE Conjugated

E16SPP102-050 EnoGene 50Tests
EUR 239

Goat anti-Rabbit IgG(H+L), PE Conjugated

E16SPP102-100 EnoGene 100Tests
EUR 343

Goat anti-Rabbit IgG(H+L), PE Conjugated

E16SPP102-100U EnoGene 100ug
EUR 239

Goat anti-Rabbit IgG(H+L), PE Conjugated

E16SPP102-500U EnoGene 500ug
EUR 343

Goat Anti-Rabbit IgG Secondary Antibody Cy3 Conjugated

L30111 SAB 1.0 ml
EUR 112

Goat Anti-Rabbit IgG Secondary Antibody FITC Conjugated

L30113 SAB 1.0 ml
EUR 97

Goat Anti-Rabbit IgG Secondary Antibody APC Conjugated

L30116 SAB 0.5 ml
EUR 191

Goat Anti-Rabbit IgG Secondary Antibody PE Conjugated

L30117 SAB 1.0 ml
EUR 191

Goat Anti-Rabbit IgG Secondary Antibody PerCP Conjugated

L30118 SAB 0.5 ml
EUR 191

Goat Anti-Rabbit IgG Secondary Antibody HRP Conjugated

L3012 SAB 1.0 ml
EUR 112

Goat Anti-Rabbit IgG Secondary Antibody Biotin Conjugated

L3014 SAB 1.0 ml
EUR 104

Goat Anti-Rabbit IgG Secondary Antibody AF488 Conjugated

L3016 SAB 1.0 ml
EUR 112

Goat Anti-Rabbit IgG Secondary Antibody AF594 Conjugated

L3017 SAB 1.0 ml
EUR 112

Goat Anti-Rabbit IgG Secondary Antibody AF647 Conjugated

L3018 SAB 1.0 ml
EUR 112

Rabbit anti-Goat IgG Secondary Antibody HRP conjugated

L3042 SAB 1.0 ml
EUR 112

Goat Anti-Rabbit IgG Secondary Antibody AF680 Conjugated

L3049 SAB 0.5 ml
EUR 126

Goat Anti-Rabbit IgG Secondary Antibody AF790 Conjugated

L30510 SAB 0.5 ml
EUR 126

Goat Anti-Rabbit IgG Secondary Antibody AMCA Conjugated

L3065 SAB 1.0 ml
EUR 97

Goat Anti-Rabbit IgG Secondary Antibody AP Conjugated

L3073 SAB 1.0 ml
EUR 119

Alpha Fluor™ 532 acid [equivalent to Alexa Fluor™ 532 acid]

1795 AAT Bioquest 10 mg
EUR 393

Goat anti Rabbit IgG Fc

70R-IG011 Fitzgerald 1.5 mg
EUR 378
Description: Goat anti Rabbit IgG Fc secondary antibody

Goat anti Rabbit IgG Fc

70R-IG017 Fitzgerald 2 mg
EUR 381
Description: Goat anti Rabbit IgG Fc secondary antibody

Goat anti Rabbit IgG Fc

41C-CB1136 Fitzgerald 2 mg
EUR 249
Description: Goat anti Rabbit IgG secondary antibody

Rabbit anti Goat IgG Fc

41R-1013 Fitzgerald 1 mg
EUR 188
Description: Rabbit anti Goat IgG Fc fragment secondary antibody

Rabbit anti Goat IgG Fc

41R-1014 Fitzgerald 1 mg
EUR 207
Description: Rabbit anti Goat IgG Fc fragment secondary antibody

Goat anti Rabbit IgG (FITC)

43-GR59 Fitzgerald 2 mg
EUR 314
Description: Goat anti Rabbit IgG secondary antibody (FITC)

Rabbit anti Goat IgG (FITC)

43C-CB0523 Fitzgerald 2 mg
EUR 286
Description: Rabbit anti Goat IgG secondary antibody (FITC)

Rabbit anti Goat IgG (rhodamine)

43C-CB0524 Fitzgerald 2 mg
EUR 291
Description: Rabbit anti Goat IgG secondary antibody (Rhodamine)

Rabbit anti Goat IgG (biotin)

43C-CB0526 Fitzgerald 2 mg
EUR 291
Description: Rabbit anti Goat IgG secondary antibody (biotin)

Rabbit anti Goat IgG (HRP)

43C-CB0527 Fitzgerald 2 mg
EUR 330
Description: Rabbit anti Goat IgG secondary antibody (HRP)

Rabbit anti Goat IgG (FITC)

43C-CB0530 Fitzgerald 2 mg
EUR 291
Description: Rabbit anti Goat IgG secondary antibody (FITC)

Rabbit anti Goat IgG (rhodamine)

43C-CB0531 Fitzgerald 2 mg
EUR 291
Description: Rabbit anti Goat IgG secondary antibody (Rhodamine)

Rabbit anti Goat IgG (biotin)

43C-CB0533 Fitzgerald 2 mg
EUR 301
Description: Rabbit anti Goat IgG secondary antibody (biotin)

Rabbit anti Goat IgG (HRP)

43C-CB0534 Fitzgerald 2 mg
EUR 350
Description: Rabbit anti Goat IgG secondary antibody (HRP)

Rabbit anti Goat IgG (FITC)

43C-CB0537 Fitzgerald 1 mg
EUR 311
Description: Rabbit anti Goat IgG secondary antibody (FITC)

Rabbit anti Goat IgG (rhodamine)

43C-CB0538 Fitzgerald 1 mg
EUR 284
Description: Rabbit anti Goat IgG secondary antibody (Rhodamine)

Rabbit anti Goat IgG (biotin)

43C-CB0540 Fitzgerald 1 mg
EUR 377
Description: Rabbit anti Goat IgG secondary antibody (biotin)

Rabbit anti Goat IgG (HRP)

43C-CB0541 Fitzgerald 1 mg
EUR 375
Description: Rabbit anti Goat IgG secondary antibody (HRP)

Goat anti Rabbit IgG (FITC)

43C-CB1137 Fitzgerald 2 mg
EUR 274
Description: Goat anti Rabbit IgG secondary antibody (FITC)

Goat anti Rabbit IgG (rhodamine)

43C-CB1138 Fitzgerald 2 mg
EUR 280
Description: Goat anti Rabbit IgG secondary antibody (Rhodamine)

Goat anti Rabbit IgG (biotin)

43C-CB1140 Fitzgerald 2 mg
EUR 316
Description: Goat anti Rabbit IgG secondary antibody (biotin)

Goat anti Rabbit IgG (HRP)

43C-CB1141 Fitzgerald 2 mg
EUR 373
Description: Goat anti Rabbit IgG secondary antibody (HRP)

Goat anti Rabbit IgG (FITC)

43C-CB1144 Fitzgerald 2 mg
EUR 313
Description: Goat anti Rabbit IgG secondary antibody (FITC)

Goat anti Rabbit IgG (rhodamine)

43C-CB1145 Fitzgerald 2 mg
EUR 330
Description: Goat anti Rabbit IgG secondary antibody (Rhodamine)

Goat anti Rabbit IgG (biotin)

43C-CB1147 Fitzgerald 2 mg
EUR 395
Description: Goat anti Rabbit IgG secondary antibody (biotin)

Goat anti Rabbit IgG (HRP)

43C-CB1148 Fitzgerald 2 mg
EUR 358
Description: Goat anti Rabbit IgG secondary antibody (HRP)

ELISA outcomes additionally confirmed that RF and ACPA titers confirmed considerably optimistic correlation with each citrullinated collagen and filaggrin OD values in sera of RA sufferers. 12G1 difficult aggravated the severity of murine arthritis. In abstract, mAb 12G1 can immediately detect citrullinated proteins in RA goal tissue and in sera of RA sufferers and 12G1 confirmed direct arthritogenic potential in vivo. This, 12G1 is perhaps helpful for analysis of RA together with seronegative RA and should assist to elucidate the pathophysiological position of citrullination in RA.

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Categories

  • 4 Host
  • 96T
  • apoptosis
  • array
  • Assay
  • Bacteria
  • Blocking
  • Combination of pembrolizumab and 125I attenuates the aggressiveness of non-small cell lung cancer.
  • Comparison of Efficacy of Topical Curcumin Gel with Triamcinolone-hyaluronidase Gel Individually and in Combination in the Treatment of Oral Submucous Fibrosis.
  • Comprehensive analysis of the long non-coding RNA-associated competitive endogenous RNA network reveals novel prognostic biomarkers in Wilms' tumor.
  • GMO
  • Goat
  • Increased expression of plakoglobin is associated with upregulated MAPK and PI3K/AKT signalling pathways in early resectable pancreatic ductal adenocarcinoma.
  • LINC00460 accelerates progression of ovarian cancer by activating transcriptional factor ZNF703.
  • Next-generation laser-based photodynamic endoscopic diagnosis using 5-aminolevulinic acid for early gastric adenocarcinoma and gastric adenoma.
  • Pig
  • Pigeon
  • Plant
  • plasmid
  • Plate
  • Prone en-bloc sacrectomy with proctectomy: A surgical approach to the inaccessible and hostile pelvis
  • Sleeve Gastrectomy: Surgical Technique, Outcomes, and Complications

Recent Posts

  • Pancreas-type ribonucleasen zijn
  • Rapid and comprehensive monoclonal antibody Characterization using microfluidic CE-MS
  • Orally administered anti-eotaxin-1 monoclonal antibody is biologically active in the gut and alleviates immune-mediated hepatitis: A novel anti-inflammatory personalized therapeutic approach
  • Preferential Light-Chain Labeling of Native Monoclonal Antibodies Improves the Properties of Fluorophore Conjugates
  • Application of tunable resistive pulse sensing for the quantification of submicron particles in pharmaceutical monoclonal antibody preparations

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Recent Posts

  • Pancreas-type ribonucleasen zijn
  • Rapid and comprehensive monoclonal antibody Characterization using microfluidic CE-MS
  • Orally administered anti-eotaxin-1 monoclonal antibody is biologically active in the gut and alleviates immune-mediated hepatitis: A novel anti-inflammatory personalized therapeutic approach
  • Preferential Light-Chain Labeling of Native Monoclonal Antibodies Improves the Properties of Fluorophore Conjugates
  • Application of tunable resistive pulse sensing for the quantification of submicron particles in pharmaceutical monoclonal antibody preparations
Breast Cancer Antibodies

Categories

  • 4 Host (6)
  • 96T (6)
  • apoptosis (6)
  • array (6)
  • Assay (5)
  • Bacteria (7)
  • Blocking (6)
  • Combination of pembrolizumab and 125I attenuates the aggressiveness of non-small cell lung cancer. (1)
  • Comparison of Efficacy of Topical Curcumin Gel with Triamcinolone-hyaluronidase Gel Individually and in Combination in the Treatment of Oral Submucous Fibrosis. (1)
  • Comprehensive analysis of the long non-coding RNA-associated competitive endogenous RNA network reveals novel prognostic biomarkers in Wilms' tumor. (1)
  • GMO (6)
  • Goat (6)
  • Increased expression of plakoglobin is associated with upregulated MAPK and PI3K/AKT signalling pathways in early resectable pancreatic ductal adenocarcinoma. (1)
  • LINC00460 accelerates progression of ovarian cancer by activating transcriptional factor ZNF703. (1)
  • Next-generation laser-based photodynamic endoscopic diagnosis using 5-aminolevulinic acid for early gastric adenocarcinoma and gastric adenoma. (1)
  • Pig (6)
  • Pigeon (6)
  • Plant (6)
  • plasmid (6)
  • Plate (5)
  • Prone en-bloc sacrectomy with proctectomy: A surgical approach to the inaccessible and hostile pelvis (1)
  • Sleeve Gastrectomy: Surgical Technique, Outcomes, and Complications (25)

Categories

  • 4 Host
  • 96T
  • apoptosis
  • array
  • Assay
  • Bacteria
  • Blocking
  • Combination of pembrolizumab and 125I attenuates the aggressiveness of non-small cell lung cancer.
  • Comparison of Efficacy of Topical Curcumin Gel with Triamcinolone-hyaluronidase Gel Individually and in Combination in the Treatment of Oral Submucous Fibrosis.
  • Comprehensive analysis of the long non-coding RNA-associated competitive endogenous RNA network reveals novel prognostic biomarkers in Wilms' tumor.
  • GMO
  • Goat
  • Increased expression of plakoglobin is associated with upregulated MAPK and PI3K/AKT signalling pathways in early resectable pancreatic ductal adenocarcinoma.
  • LINC00460 accelerates progression of ovarian cancer by activating transcriptional factor ZNF703.
  • Next-generation laser-based photodynamic endoscopic diagnosis using 5-aminolevulinic acid for early gastric adenocarcinoma and gastric adenoma.
  • Pig
  • Pigeon
  • Plant
  • plasmid
  • Plate
  • Prone en-bloc sacrectomy with proctectomy: A surgical approach to the inaccessible and hostile pelvis
  • Sleeve Gastrectomy: Surgical Technique, Outcomes, and Complications
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