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Blockade of CHRNB2 signaling with a therapeutic monoclonal antibody attenuates the aggressiveness of gastric cancer cells

Blockade of CHRNB2 signaling with a therapeutic monoclonal antibody attenuates the aggressiveness of gastric cancer cells

Posted on August 28, 2021September 4, 2021 by Cody

Here, we evaluated the therapeutic potential of antibodies (Abs) focusing on cholinergic receptor nicotinic beta 2 subunit (CHRNB2) in gastric cancer. To examine the results of these Abs on malignant phenotypes in vitro and in mouse xenograft fashions, we generated gene knockouts by way of genome enhancing, carried out RNA interference-mediated knockdown of gene expression, and ectopically expressed CHRNB2 in gastric cancer cells. The results of anti-CHRNB2 Abs on the proliferation of cancer cells had been evaluated each in vitro and in vivo. We decided the results of Chrnb2 deficiency on mice and the medical significance of CHRNB2 expression in gastric cancer medical specimens.

Knockdown of CHRNB2 attenuated gastric cancer cell proliferation, whereas compelled overexpression of CHRNB2 elevated cell proliferation. Knockout of CHRNB2 considerably influenced cell survival and capabilities related with metastasis. The results of polyclonal Abs focusing on the C- and N-termini of CHRNB2 guided the improvement of anti-CHRNB2 monoclonal Abs that inhibited the development of gastric cancer cells in vitro and in vivo. Pathway evaluation revealed that CHRNB2 interfered with signaling by way of the PI3K-AKT and JAK-STAT pathways. Chrnb2-deficient mice exhibited regular replica, organ capabilities, and motor capabilities. CHRNB2 regulates a number of oncological phenotypes related with metastasis, and blockade of CHRNB2 expression utilizing particular Abs exhibits promise for controlling metastasis in gastric cancer.

About 25% of sufferers with IgA nephropathy (IgAN) progress to stage 5 persistent kidney illness (CKD) after years of evolution. Various instruments have been developed in recent times designed to foretell which of the sufferers will had poorer outcomes. The worth of circulating galactosyl-deficient IgA1 (Gd-IgA1) has been associated to a worse evolution of IgAN in a number of research. There are additionally some publications that relate greater APRIL values with a worse evolution. Recently, a new technique has been developed that enables measuring the worth of circulating Gd-IgA1 in a less complicated manner than these beforehand obtainable. The goal of this research is to investigate the affect of circulating Gd-IgA1, measured by this technique, on the development of IgAN.

Monoclonal Antibody Targeting the CD154 Cleavage Site Inhibits CD40-Dependent and -Independent Cleavage of CD154 from the Cell Surface

In addition to the membrane-bound molecule, soluble CD154 (sCD154) can also be detected at excessive ranges in the medium of activated T cells and platelets and in the serum of sufferers affected by completely different inflammatory ailments. This sCD154 is the consequence of cleavage of the full-length molecule between the glutamic acid residue at place 112 (E112) and methionine at place 113 (M113) and will be derived from the intracellular milieu and from cleavage of cell floor molecules. We have just lately reported that substitution of each E112 and M113 by alanine inhibits intracellular and CD40-induced membrane cleavage of CD154 and procures to CD154 an elevated organic operate as in contrast with cleavable CD154.

Blockade of CHRNB2 signaling with a therapeutic monoclonal antibody attenuates the aggressiveness of gastric cancer cells

Thus, on this research, and in the intention of growing instruments inhibiting cleavage of CD154 from the cell floor, we generated a panel of anti-human CD154 mAbs. One of the derived mAbs that didn’t alter the binding of sCD154 to CD40, named on this research Clone eight mAb, completely misplaced its binding exercise in opposition to cells expressing CD154 mutated at its E112 and M113 residues. Treatment with Clone eight mAb was proven to fully abolish CD40-dependent and -independent cleavage of CD154 from the cell floor. Our research is highlighting the improvement and characterization of an modern therapeutic device succesful of inhibiting the launch/cleavage of CD154 from cells and thus sustaining its availability on the cell floor and the excessive in all probability of growing its efficiency as an activator of CD40-induced responses.

In this quasi-experimental pre-/postimplementation research, we estimated the effectiveness of MAb remedy inside 7 days of symptom onset in high-risk ambulatory adults with COVID-19. The main consequence was a composite of emergency division visits or hospitalizations inside 14 days of optimistic check. Secondary outcomes included adversarial occasions and 14-day mortality. The common remedy impact in the handled for MAb remedy was estimated utilizing inverse chance of remedy weighting and the affect of MAb implementation utilizing propensity-weighted interrupted time sequence evaluation.

Electrostatic Spray Drying for Monoclonal Antibody Formulation

This research explored the feasibility of electrostatic spray drying for producing a monoclonal antibody (mAb) powder formulation at decrease drying temperatures than typical spray drying and its impact on protein stability. A mAb formulation was dried by both typical spray drying or electrostatic spray drying with cost (ESD). The protein powders had been then characterised utilizing solid-state Fourier remodel infrared spectroscopy (ssFTIR), differential scanning calorimetry (DSC), dimension exclusion chromatography (SEC), and solid-state hydrogen/deuterium alternate with mass spectrometry (ssHDX-MS).

Particle characterizations reminiscent of BET floor space, particle dimension distribution, and particle morphology had been additionally carried out. Conventional spray drying of the mAb formulation at the inlet temperature of 70°C didn’t generate dry powders as a consequence of poor drying effectivity; electrostatic spray drying at the similar temperature at 5kV enabled the formation of powder formulation with passable moisture contents. Deconvoluted peak areas of deuterated samples from the ssHDX-MS research confirmed a good correlation with the loss of the monomeric peak space measured by dimension exclusion chromatography in the 90-day accelerated stability research carried out at 40°C.

Alexa Fluor 594-conjugated Goat Anti-Rabbit IgG (H+L)

E45G021N EnoGene 50 ul
EUR 57.25

Goat Anti-Mouse IgG (H+L)(Alexa Fluor 488 conjugated)

MBS2548768-006mL MyBiosource 0.06mL
EUR 95

Goat Anti-Mouse IgG (H+L)(Alexa Fluor 488 conjugated)

MBS2548768-012mL MyBiosource 0.12mL
EUR 105

Goat Anti-Mouse IgG (H+L)(Alexa Fluor 488 conjugated)

MBS2548768-02mL MyBiosource 0.2mL
EUR 125

Goat Anti-Mouse IgG (H+L)(Alexa Fluor 488 conjugated)

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EUR 515

Goat anti-Mouse IgG(H+L) (Alexa Fluor® 594 Conjugate)

S0B4010-100uL Starter Biotechnology Co Ltd 100 μL
EUR 70

Goat anti-Mouse IgG(H+L) (Alexa Fluor® 594 Conjugate)

S0B4010-1mL Starter Biotechnology Co Ltd 1 mL
EUR 500

Goat anti-Mouse IgG(H+L) (Alexa Fluor® 594 Conjugate)

S0B4010-25uL Starter Biotechnology Co Ltd 25 μL
EUR 20

Goat anti-Mouse IgG(H+L) (Alexa Fluor® 594 Conjugate)

S0B4010-each Starter Biotechnology Co Ltd each Ask for price

Alexa Fluor 405-conjugated Goat Anti-Mouse IgG (H+L)

E45G010N EnoGene 50 ul
EUR 57.25

Goat Anti-Rabbit IgG (H+L)(Alexa Fluor 488 conjugated)

MBS2548767-006mL MyBiosource 0.06mL
EUR 95

Goat Anti-Rabbit IgG (H+L)(Alexa Fluor 488 conjugated)

MBS2548767-012mL MyBiosource 0.12mL
EUR 105

Goat Anti-Rabbit IgG (H+L)(Alexa Fluor 488 conjugated)

MBS2548767-02mL MyBiosource 0.2mL
EUR 125

Goat Anti-Rabbit IgG (H+L)(Alexa Fluor 488 conjugated)

MBS2548767-5x02mL MyBiosource 5x0.2mL
EUR 515

Goat anti-Rabbit IgG(H+L) (Alexa Fluor® 594 Conjugate)

S0B4007-100L Starter Biotechnology Co Ltd 100 µL
EUR 78

Goat anti-Rabbit IgG(H+L) (Alexa Fluor® 594 Conjugate)

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EUR 500

Goat anti-Rabbit IgG(H+L) (Alexa Fluor® 594 Conjugate)

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EUR 20

Goat anti-Rabbit IgG(H+L) (Alexa Fluor® 594 Conjugate)

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Donkey Anti-Goat IgG (H+L), Alexa Fluor® 594 Conjugated

Ab8011-001 GenDepot 1mg
EUR 400.8

Alexa Fluor 405-conjugated Goat Anti-Rabbit IgG (H+L)

E45G016N EnoGene 50 ul
EUR 57.25

Goat anti-Mouse IgG(H+L) (Alexa Fluor® 647 Conjugate)

S0B4008-100L Starter Biotechnology Co Ltd 100 µL
EUR 78

Goat anti-Mouse IgG(H+L) (Alexa Fluor® 647 Conjugate)

S0B4008-1mL Starter Biotechnology Co Ltd 1 mL
EUR 500

Goat anti-Mouse IgG(H+L) (Alexa Fluor® 647 Conjugate)

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EUR 20

Goat anti-Mouse IgG(H+L) (Alexa Fluor® 647 Conjugate)

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Goat anti-Rabbit IgG(H+L) (Alexa Fluor® 488 Conjugate)

S0B4004-100L Starter Biotechnology Co Ltd 100 µL
EUR 78

Goat anti-Rabbit IgG(H+L) (Alexa Fluor® 488 Conjugate)

S0B4004-1mL Starter Biotechnology Co Ltd 1 mL
EUR 500

Goat anti-Rabbit IgG(H+L) (Alexa Fluor® 488 Conjugate)

S0B4004-25L Starter Biotechnology Co Ltd 25 µL
EUR 20

Goat anti-Rabbit IgG(H+L) (Alexa Fluor® 488 Conjugate)

S0B4004-500L Starter Biotechnology Co Ltd 500 µL
EUR 280

Goat anti-Rabbit IgG (H+L) (Alexa Fluor® 647 Conjugate)

S0B4005-100L Starter Biotechnology Co Ltd 100 µL
EUR 78

Goat anti-Rabbit IgG (H+L) (Alexa Fluor® 647 Conjugate)

S0B4005-1mL Starter Biotechnology Co Ltd 1 mL
EUR 500

Goat anti-Rabbit IgG (H+L) (Alexa Fluor® 647 Conjugate)

S0B4005-25L Starter Biotechnology Co Ltd 25 µL
EUR 20

Goat anti-Rabbit IgG (H+L) (Alexa Fluor® 647 Conjugate)

S0B4005-each Starter Biotechnology Co Ltd each Ask for price

Lipopolysaccharide, Alexa Fluor 594 conjugated

LPS-05AF Creative BioMart 100µg
EUR 615.2

Goat Anti-Mouse IgG (H&L) - Alexa Fluor 594

DL87362A-100ul DL Develop 100 ul
EUR 140
Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads.

Goat Anti-Mouse IgG (H&L) - Alexa Fluor 594

DL87362A-500ul DL Develop 500 ul
EUR 330
Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads.

Goat Anti-Mouse IgG (H&L) - Alexa Fluor 594

E38A3608 EnoGene 100μL
EUR 125

Goat Anti-Mouse IgG (H&L) - Alexa Fluor 594

YLF0110-100ul Shanghai YL Biotech 100 ul
EUR 100
Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads.

Goat Anti-Mouse IgG (H&L) - Alexa Fluor 594

YLF0110-1ml Shanghai YL Biotech 1 ml
EUR 490
Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads.

Goat Anti-Mouse IgG (H&L) - Alexa Fluor 594

YLF0110-500ul Shanghai YL Biotech 500 ul
EUR 300
Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads.

Goat Anti-Human IgG Fc - Alexa Fluor 594

DL87358A-100ul DL Develop 100 ul
EUR 155
Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads.

Goat Anti-Human IgG Fc - Alexa Fluor 594

DL87358A-500ul DL Develop 500 ul
EUR 350
Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads.

Goat Anti-Human IgG Fc - Alexa Fluor 594

YLF0339-100ul Shanghai YL Biotech 100 ul
EUR 130
Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads.

Goat Anti-Human IgG Fc - Alexa Fluor 594

YLF0339-1ml Shanghai YL Biotech 1 ml
EUR 480
Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads.

Goat Anti-Human IgG Fc - Alexa Fluor 594

YLF0339-500ul Shanghai YL Biotech 500 ul
EUR 290
Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads.

Donkey Anti-Rabbit IgG (H+L), Alexa Fluor® 488 Conjugated

Ab8032-001 GenDepot 0.5mg
EUR 522

Goat Anti-Mouse IgG(H+L)(Elab Fluor®594 conjugated)

E-AB-1059-120uL Elabscience Biotech 120uL
EUR 34
Description: Elab Fluor®594

Goat Anti-Mouse IgG(H+L)(Elab Fluor®594 conjugated)

E-AB-1059-500uL Elabscience Biotech 500uL
EUR 100
Description: Elab Fluor®594

Goat Anti-Mouse IgG(H+L)(Elab Fluor®594 conjugated)

E-AB-1059-60uL Elabscience Biotech 60uL
EUR 21
Description: Elab Fluor®594

Goat Anti-Mouse IgG(H+L)(Elab Fluor®594 conjugated)

E-AB-1059-each Elabscience Biotech each Ask for price
Description: Elab Fluor®594

Goat Anti-Human IgG Fab - Alexa Fluor 594

DL87357A-100ul DL Develop 100 ul
EUR 190
Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads.

Goat Anti-Human IgG Fab - Alexa Fluor 594

DL87357A-500ul DL Develop 500 ul
EUR 280
Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads.

Goat Anti-Human IgG Fab - Alexa Fluor 594

E38A3603 EnoGene 100μL
EUR 125

Goat Anti-Human IgG Fab - Alexa Fluor 594

YLF0558-100ul Shanghai YL Biotech 100 ul
EUR 130
Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads.

Goat Anti-Human IgG Fab - Alexa Fluor 594

YLF0558-1ml Shanghai YL Biotech 1 ml
EUR 300
Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads.

Goat Anti-Human IgG Fab - Alexa Fluor 594

YLF0558-500ul Shanghai YL Biotech 500 ul
EUR 210
Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads.

Mouse IgG1, kappa Isotype Control (Alexa Fluor 488 Conjugated)

MBS2557740-100Tests MyBiosource 100Tests
EUR 175

Mouse IgG1, kappa Isotype Control (Alexa Fluor 488 Conjugated)

MBS2557740-200Tests MyBiosource 200Tests
EUR 235

Mouse IgG1, kappa Isotype Control (Alexa Fluor 488 Conjugated)

MBS2557740-20Tests MyBiosource 20Tests
EUR 115

Mouse IgG1, kappa Isotype Control (Alexa Fluor 488 Conjugated)

MBS2557740-5x200Tests MyBiosource 5x200Tests
EUR 1045

Mouse IgG1, kappa Isotype Control (Alexa Fluor 647 Conjugated)

MBS2557741-100Tests MyBiosource 100Tests
EUR 175

Mouse IgG1, kappa Isotype Control (Alexa Fluor 647 Conjugated)

MBS2557741-200Tests MyBiosource 200Tests
EUR 235

Mouse IgG1, kappa Isotype Control (Alexa Fluor 647 Conjugated)

MBS2557741-20Tests MyBiosource 20Tests
EUR 115

Mouse IgG1, kappa Isotype Control (Alexa Fluor 647 Conjugated)

MBS2557741-5x200Tests MyBiosource 5x200Tests
EUR 1045

Mouse IgG1, kappa Isotype Control (Alexa Fluor 488 Conjugated)

MBS2557755-0025mg MyBiosource 0.025mg
EUR 115

Mouse IgG1, kappa Isotype Control (Alexa Fluor 488 Conjugated)

MBS2557755-01mg MyBiosource 0.1mg
EUR 175

Mouse IgG1, kappa Isotype Control (Alexa Fluor 488 Conjugated)

MBS2557755-5x01mg MyBiosource 5x0.1mg
EUR 785

Mouse IgG1, kappa Isotype Control (Alexa Fluor 647 Conjugated)

MBS2557756-0025mg MyBiosource 0.025mg
EUR 115

Mouse IgG1, kappa Isotype Control (Alexa Fluor 647 Conjugated)

MBS2557756-01mg MyBiosource 0.1mg
EUR 175

Mouse IgG1, kappa Isotype Control (Alexa Fluor 647 Conjugated)

MBS2557756-5x01mg MyBiosource 5x0.1mg
EUR 785

Goat Anti-Pig IgG (H&L) - Alexa Fluor 594

DL87364A-100ul DL Develop 100 ul
EUR 155
Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads.

Goat Anti-Pig IgG (H&L) - Alexa Fluor 594

DL87364A-500ul DL Develop 500 ul
EUR 350
Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads.

Goat Anti-Pig IgG (H&L) - Alexa Fluor 594

E38A3610 EnoGene 100μL
EUR 125

Goat Anti-Pig IgG (H&L) - Alexa Fluor 594

YLF0343-100ul Shanghai YL Biotech 100 ul
EUR 130
Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads.

Goat Anti-Pig IgG (H&L) - Alexa Fluor 594

YLF0343-1ml Shanghai YL Biotech 1 ml
EUR 480
Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads.

Goat Anti-Pig IgG (H&L) - Alexa Fluor 594

YLF0343-500ul Shanghai YL Biotech 500 ul
EUR 290
Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads.

Goat Anti-Mouse IgG F(ab')2(Elab Fluor®594 conjugated)

E-AB-1105-120uL Elabscience Biotech 120uL
EUR 34
Description: Elab Fluor®594

Goat Anti-Mouse IgG F(ab')2(Elab Fluor®594 conjugated)

E-AB-1105-500uL Elabscience Biotech 500uL
EUR 100
Description: Elab Fluor®594

Goat Anti-Mouse IgG F(ab')2(Elab Fluor®594 conjugated)

E-AB-1105-60uL Elabscience Biotech 60uL
EUR 21
Description: Elab Fluor®594

Goat Anti-Mouse IgG F(ab')2(Elab Fluor®594 conjugated)

E-AB-1105-each Elabscience Biotech each Ask for price
Description: Elab Fluor®594

Mouse IgG2a, kappa Isotype Control (Alexa Fluor 488 Conjugated)

MBS2557767-100Tests MyBiosource 100Tests
EUR 175

Mouse IgG2a, kappa Isotype Control (Alexa Fluor 488 Conjugated)

MBS2557767-200Tests MyBiosource 200Tests
EUR 235

Mouse IgG2a, kappa Isotype Control (Alexa Fluor 488 Conjugated)

MBS2557767-20Tests MyBiosource 20Tests
EUR 115

Mouse IgG2a, kappa Isotype Control (Alexa Fluor 488 Conjugated)

MBS2557767-5x200Tests MyBiosource 5x200Tests
EUR 1045

Mouse IgG2a, kappa Isotype Control (Alexa Fluor 647 Conjugated)

MBS2557768-100Tests MyBiosource 100Tests
EUR 175

Mouse IgG2a, kappa Isotype Control (Alexa Fluor 647 Conjugated)

MBS2557768-200Tests MyBiosource 200Tests
EUR 235

Mouse IgG2a, kappa Isotype Control (Alexa Fluor 647 Conjugated)

MBS2557768-20Tests MyBiosource 20Tests
EUR 115

Mouse IgG2a, kappa Isotype Control (Alexa Fluor 647 Conjugated)

MBS2557768-5x200Tests MyBiosource 5x200Tests
EUR 1045

Mouse IgG2a, kappa Isotype Control (Alexa Fluor 488 Conjugated)

MBS2557782-0025mg MyBiosource 0.025mg
EUR 115

Mouse IgG2a, kappa Isotype Control (Alexa Fluor 488 Conjugated)

MBS2557782-01mg MyBiosource 0.1mg
EUR 175

Mouse IgG2a, kappa Isotype Control (Alexa Fluor 488 Conjugated)

MBS2557782-5x01mg MyBiosource 5x0.1mg
EUR 785

Mouse IgG2a, kappa Isotype Control (Alexa Fluor 647 Conjugated)

MBS2557783-0025mg MyBiosource 0.025mg
EUR 115

Mouse IgG2a, kappa Isotype Control (Alexa Fluor 647 Conjugated)

MBS2557783-01mg MyBiosource 0.1mg
EUR 175

Mouse IgG2a, kappa Isotype Control (Alexa Fluor 647 Conjugated)

MBS2557783-5x01mg MyBiosource 5x0.1mg
EUR 785

Mouse IgG2b, kappa Isotype Control (Alexa Fluor 488 Conjugated)

MBS2557794-100Tests MyBiosource 100Tests
EUR 175

Mouse IgG2b, kappa Isotype Control (Alexa Fluor 488 Conjugated)

MBS2557794-200Tests MyBiosource 200Tests
EUR 235

Mouse IgG2b, kappa Isotype Control (Alexa Fluor 488 Conjugated)

MBS2557794-20Tests MyBiosource 20Tests
EUR 115

Mouse IgG2b, kappa Isotype Control (Alexa Fluor 488 Conjugated)

MBS2557794-5x200Tests MyBiosource 5x200Tests
EUR 1045

Mouse IgG2b, kappa Isotype Control (Alexa Fluor 647 Conjugated)

MBS2557795-100Tests MyBiosource 100Tests
EUR 175

Mouse IgG2b, kappa Isotype Control (Alexa Fluor 647 Conjugated)

MBS2557795-200Tests MyBiosource 200Tests
EUR 235

Mouse IgG2b, kappa Isotype Control (Alexa Fluor 647 Conjugated)

MBS2557795-20Tests MyBiosource 20Tests
EUR 115

Mouse IgG2b, kappa Isotype Control (Alexa Fluor 647 Conjugated)

MBS2557795-5x200Tests MyBiosource 5x200Tests
EUR 1045

Mouse IgG2b, kappa Isotype Control (Alexa Fluor 488 Conjugated)

MBS2557809-0025mg MyBiosource 0.025mg
EUR 115

Mouse IgG2b, kappa Isotype Control (Alexa Fluor 488 Conjugated)

MBS2557809-01mg MyBiosource 0.1mg
EUR 175

Mouse IgG2b, kappa Isotype Control (Alexa Fluor 488 Conjugated)

MBS2557809-5x01mg MyBiosource 5x0.1mg
EUR 785

Mouse IgG2b, kappa Isotype Control (Alexa Fluor 647 Conjugated)

MBS2557810-0025mg MyBiosource 0.025mg
EUR 115

Mouse IgG2b, kappa Isotype Control (Alexa Fluor 647 Conjugated)

MBS2557810-01mg MyBiosource 0.1mg
EUR 175

Mouse IgG2b, kappa Isotype Control (Alexa Fluor 647 Conjugated)

MBS2557810-5x01mg MyBiosource 5x0.1mg
EUR 785

Goat Anti-Human IgG (H&L) - Alexa Fluor 594

DL87356A-100ul DL Develop 100 ul
EUR 140
Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads.

Goat Anti-Human IgG (H&L) - Alexa Fluor 594

DL87356A-500ul DL Develop 500 ul
EUR 330
Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads.

Goat Anti-Human IgG (H&L) - Alexa Fluor 594

E38A3602 EnoGene 100μL
EUR 125

Goat Anti-Human IgG (H&L) - Alexa Fluor 594

YLF0109-100ul Shanghai YL Biotech 100 ul
EUR 100
Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads.

Goat Anti-Human IgG (H&L) - Alexa Fluor 594

YLF0109-1ml Shanghai YL Biotech 1 ml
EUR 490
Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads.

Goat Anti-Human IgG (H&L) - Alexa Fluor 594

YLF0109-500ul Shanghai YL Biotech 500 ul
EUR 300
Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads.

Goat Anti-Rabbit IgG (H&L) - Alexa Fluor 594

DL87365A-100ul DL Develop 100 ul
EUR 140
Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads.

Goat Anti-Rabbit IgG (H&L) - Alexa Fluor 594

DL87365A-500ul DL Develop 500 ul
EUR 330
Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads.

Goat Anti-Rabbit IgG (H&L) - Alexa Fluor 594

E38A3611 EnoGene 100μL
EUR 125

Goat Anti-Rabbit IgG (H&L) - Alexa Fluor 594

YLF0111-100ul Shanghai YL Biotech 100 ul
EUR 100
Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads.

Goat Anti-Rabbit IgG (H&L) - Alexa Fluor 594

YLF0111-1ml Shanghai YL Biotech 1 ml
EUR 490
Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads.

Goat Anti-Rabbit IgG (H&L) - Alexa Fluor 594

YLF0111-500ul Shanghai YL Biotech 500 ul
EUR 300
Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads.

Goat Anti-Mouse IgG(H+L) pAb, Alexa Fluor 594

E40SA2134 EnoGene 100ul
EUR 120

Goat Anti-Mouse IgG(H+L) pAb, Alexa Fluor 594

E40SA2155 EnoGene 100ul
EUR 120

Donkey anti Goat IgG (H + L) (Alexa Fluor 594)

43R-ID005AF Fitzgerald 500 ug
EUR 333
Description: Donkey anti Goat IgG (H + L) secondary antibody (Alexa Fluor 594)

Goat Anti-Rabbit IgG(H+L)(Elab Fluor®594 conjugated)

E-AB-1060-120uL Elabscience Biotech 120uL
EUR 34
Description: Elab Fluor®594

Goat Anti-Rabbit IgG(H+L)(Elab Fluor®594 conjugated)

E-AB-1060-500uL Elabscience Biotech 500uL
EUR 100
Description: Elab Fluor®594

Goat Anti-Rabbit IgG(H+L)(Elab Fluor®594 conjugated)

E-AB-1060-60uL Elabscience Biotech 60uL
EUR 21
Description: Elab Fluor®594

Goat Anti-Rabbit IgG(H+L)(Elab Fluor®594 conjugated)

E-AB-1060-each Elabscience Biotech each Ask for price
Description: Elab Fluor®594

Goat Anti-Human IgG+IgM+IgA - Alexa Fluor 594

DL87360A-100ul DL Develop 100 ul
EUR 155
Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads.

Goat Anti-Human IgG+IgM+IgA - Alexa Fluor 594

DL87360A-500ul DL Develop 500 ul
EUR 350
Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads.

Goat Anti-Human IgG+IgM+IgA - Alexa Fluor 594

YLF0340-100ul Shanghai YL Biotech 100 ul
EUR 130
Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads.

Goat Anti-Human IgG+IgM+IgA - Alexa Fluor 594

YLF0340-1ml Shanghai YL Biotech 1 ml
EUR 480
Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads.

Goat Anti-Human IgG+IgM+IgA - Alexa Fluor 594

YLF0340-500ul Shanghai YL Biotech 500 ul
EUR 290
Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads.

Goat Anti-Human IgG gamma chain - Alexa Fluor 594

DL87359A-100ul DL Develop 100 ul
EUR 190
Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads.

Goat Anti-Human IgG gamma chain - Alexa Fluor 594

DL87359A-500ul DL Develop 500 ul
EUR 280
Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads.

Goat Anti-Human IgG gamma chain - Alexa Fluor 594

E38A3605 EnoGene 100μL
EUR 125

Goat Anti-Human IgG gamma chain - Alexa Fluor 594

YLF0559-100ul Shanghai YL Biotech 100 ul
EUR 130
Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads.

Goat Anti-Human IgG gamma chain - Alexa Fluor 594

YLF0559-1ml Shanghai YL Biotech 1 ml
EUR 300
Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads.

Goat Anti-Human IgG gamma chain - Alexa Fluor 594

YLF0559-500ul Shanghai YL Biotech 500 ul
EUR 210
Description: The antibody was isolated from antisera by immunoaffinity chromatography using antigens coupled to agarose beads.

Goat Anti-Human IgG F(ab')2 - Alexa Fluor 594

DL87396A-100ul DL Develop 100 ul
EUR 155
Description: The antibody was isolated from ascitic by immunoaffinity chromatography using antigens coupled to agarose beads.

Goat Anti-Human IgG F(ab')2 - Alexa Fluor 594

DL87396A-500ul DL Develop 500 ul
EUR 350
Description: The antibody was isolated from ascitic by immunoaffinity chromatography using antigens coupled to agarose beads.

Goat Anti-Human IgG F(ab')2 - Alexa Fluor 594

E38A3646 EnoGene 100μL
EUR 125

Goat Anti-Human IgG F(ab')2 - Alexa Fluor 594

YLF0362-100ul Shanghai YL Biotech 100 ul
EUR 130
Description: The antibody was isolated from ascitic by immunoaffinity chromatography using antigens coupled to agarose beads.

Goat Anti-Human IgG F(ab')2 - Alexa Fluor 594

YLF0362-1ml Shanghai YL Biotech 1 ml
EUR 480
Description: The antibody was isolated from ascitic by immunoaffinity chromatography using antigens coupled to agarose beads.

Goat Anti-Human IgG F(ab')2 - Alexa Fluor 594

YLF0362-500ul Shanghai YL Biotech 500 ul
EUR 290
Description: The antibody was isolated from ascitic by immunoaffinity chromatography using antigens coupled to agarose beads.

Anti-Human/Mouse/Rat CD47 Monoclonal Antibody (Alexa Fluor 488 Conjugated)

MBS2558107-100Tests MyBiosource 100Tests
EUR 265

Anti-Human/Mouse/Rat CD47 Monoclonal Antibody (Alexa Fluor 488 Conjugated)

MBS2558107-200Tests MyBiosource 200Tests
EUR 360

Anti-Human/Mouse/Rat CD47 Monoclonal Antibody (Alexa Fluor 488 Conjugated)

MBS2558107-20Tests MyBiosource 20Tests
EUR 155

Anti-Human/Mouse/Rat CD47 Monoclonal Antibody (Alexa Fluor 488 Conjugated)

MBS2558107-5x200Tests MyBiosource 5x200Tests
EUR 1610

Goat Anti-Rabbit IgG F(ab')2(Elab Fluor®594 conjugated)

E-AB-1106-120uL Elabscience Biotech 120uL
EUR 34
Description: Elab Fluor®594

Goat Anti-Rabbit IgG F(ab')2(Elab Fluor®594 conjugated)

E-AB-1106-500uL Elabscience Biotech 500uL
EUR 100
Description: Elab Fluor®594

Goat Anti-Rabbit IgG F(ab')2(Elab Fluor®594 conjugated)

E-AB-1106-60uL Elabscience Biotech 60uL
EUR 21
Description: Elab Fluor®594

Goat Anti-Rabbit IgG F(ab')2(Elab Fluor®594 conjugated)

E-AB-1106-each Elabscience Biotech each Ask for price
Description: Elab Fluor®594

Armenian Hamster IgG Isotype Control (Alexa Fluor 488 Conjugated)

MBS2557902-100Tests MyBiosource 100Tests
EUR 195

Armenian Hamster IgG Isotype Control (Alexa Fluor 488 Conjugated)

MBS2557902-200Tests MyBiosource 200Tests
EUR 265

Armenian Hamster IgG Isotype Control (Alexa Fluor 488 Conjugated)

MBS2557902-20Tests MyBiosource 20Tests
EUR 125

Armenian Hamster IgG Isotype Control (Alexa Fluor 488 Conjugated)

MBS2557902-50Tests MyBiosource 50Tests
EUR 155

Armenian Hamster IgG Isotype Control (Alexa Fluor 488 Conjugated)

MBS2557902-5x200Tests MyBiosource 5x200Tests
EUR 1115

Armenian Hamster IgG Isotype Control (Alexa Fluor 647 Conjugated)

MBS2557903-100Tests MyBiosource 100Tests
EUR 175

Armenian Hamster IgG Isotype Control (Alexa Fluor 647 Conjugated)

MBS2557903-200Tests MyBiosource 200Tests
EUR 235

Armenian Hamster IgG Isotype Control (Alexa Fluor 647 Conjugated)

MBS2557903-20Tests MyBiosource 20Tests
EUR 115

Armenian Hamster IgG Isotype Control (Alexa Fluor 647 Conjugated)

MBS2557903-5x200Tests MyBiosource 5x200Tests
EUR 1045

Armenian Hamster IgG Isotype Control (Alexa Fluor 488 Conjugated)

MBS2557917-0025mg MyBiosource 0.025mg
EUR 115

Armenian Hamster IgG Isotype Control (Alexa Fluor 488 Conjugated)

MBS2557917-01mg MyBiosource 0.1mg
EUR 175

Armenian Hamster IgG Isotype Control (Alexa Fluor 488 Conjugated)

MBS2557917-5x01mg MyBiosource 5x0.1mg
EUR 785

Armenian Hamster IgG Isotype Control (Alexa Fluor 647 Conjugated)

MBS2557918-0025mg MyBiosource 0.025mg
EUR 115

Armenian Hamster IgG Isotype Control (Alexa Fluor 647 Conjugated)

MBS2557918-01mg MyBiosource 0.1mg
EUR 175

Armenian Hamster IgG Isotype Control (Alexa Fluor 647 Conjugated)

MBS2557918-5x01mg MyBiosource 5x0.1mg
EUR 785
×

Low-temperature (70°C inlet temperature) drying with an electrostatic cost (5kV) led to higher protein bodily stability as in contrast with the samples spray-dried at the excessive temperature (130°C inlet temperature) with out cost. This research exhibits that electrostatic spray drying can produce strong monoclonal antibody formulation at decrease inlet temperature than conventional spray drying with higher bodily stability.

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Categories

  • 4 Host
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  • Bacteria
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  • Combination of pembrolizumab and 125I attenuates the aggressiveness of non-small cell lung cancer.
  • Comparison of Efficacy of Topical Curcumin Gel with Triamcinolone-hyaluronidase Gel Individually and in Combination in the Treatment of Oral Submucous Fibrosis.
  • Comprehensive analysis of the long non-coding RNA-associated competitive endogenous RNA network reveals novel prognostic biomarkers in Wilms' tumor.
  • GMO
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  • Increased expression of plakoglobin is associated with upregulated MAPK and PI3K/AKT signalling pathways in early resectable pancreatic ductal adenocarcinoma.
  • LINC00460 accelerates progression of ovarian cancer by activating transcriptional factor ZNF703.
  • Next-generation laser-based photodynamic endoscopic diagnosis using 5-aminolevulinic acid for early gastric adenocarcinoma and gastric adenoma.
  • Pig
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  • Prone en-bloc sacrectomy with proctectomy: A surgical approach to the inaccessible and hostile pelvis
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Breast Cancer Antibodies

Categories

  • 4 Host (6)
  • 96T (6)
  • apoptosis (7)
  • array (6)
  • Assay (6)
  • Bacteria (7)
  • Blocking (6)
  • Combination of pembrolizumab and 125I attenuates the aggressiveness of non-small cell lung cancer. (1)
  • Comparison of Efficacy of Topical Curcumin Gel with Triamcinolone-hyaluronidase Gel Individually and in Combination in the Treatment of Oral Submucous Fibrosis. (1)
  • Comprehensive analysis of the long non-coding RNA-associated competitive endogenous RNA network reveals novel prognostic biomarkers in Wilms' tumor. (1)
  • GMO (6)
  • Goat (6)
  • Increased expression of plakoglobin is associated with upregulated MAPK and PI3K/AKT signalling pathways in early resectable pancreatic ductal adenocarcinoma. (1)
  • LINC00460 accelerates progression of ovarian cancer by activating transcriptional factor ZNF703. (1)
  • Next-generation laser-based photodynamic endoscopic diagnosis using 5-aminolevulinic acid for early gastric adenocarcinoma and gastric adenoma. (1)
  • Pig (6)
  • Pigeon (6)
  • Plant (6)
  • plasmid (6)
  • Plate (5)
  • Prone en-bloc sacrectomy with proctectomy: A surgical approach to the inaccessible and hostile pelvis (1)
  • Sleeve Gastrectomy: Surgical Technique, Outcomes, and Complications (34)

Categories

  • 4 Host
  • 96T
  • apoptosis
  • array
  • Assay
  • Bacteria
  • Blocking
  • Combination of pembrolizumab and 125I attenuates the aggressiveness of non-small cell lung cancer.
  • Comparison of Efficacy of Topical Curcumin Gel with Triamcinolone-hyaluronidase Gel Individually and in Combination in the Treatment of Oral Submucous Fibrosis.
  • Comprehensive analysis of the long non-coding RNA-associated competitive endogenous RNA network reveals novel prognostic biomarkers in Wilms' tumor.
  • GMO
  • Goat
  • Increased expression of plakoglobin is associated with upregulated MAPK and PI3K/AKT signalling pathways in early resectable pancreatic ductal adenocarcinoma.
  • LINC00460 accelerates progression of ovarian cancer by activating transcriptional factor ZNF703.
  • Next-generation laser-based photodynamic endoscopic diagnosis using 5-aminolevulinic acid for early gastric adenocarcinoma and gastric adenoma.
  • Pig
  • Pigeon
  • Plant
  • plasmid
  • Plate
  • Prone en-bloc sacrectomy with proctectomy: A surgical approach to the inaccessible and hostile pelvis
  • Sleeve Gastrectomy: Surgical Technique, Outcomes, and Complications
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