Oncomoculin

Oncomodulin antibodies for the lab

These mono and polyclonal antibodies can be bought from Genprice Inc.

Inner Ear Proteins as Potential Biomarkers.

The purpose of this manuscript is to identify proteins exclusive to the inner ear based on published research to identify potential candidate biomarkers and guide future inner ear research.

Literature on inner ear proteins published on Pubmed, Google Scholar, and Scopus was reviewed using key words such as “inner ear molecule,” “inner ear exclusive protein,” and several specific protein searches such as “prestin” based on findings from the initial searches.Studies were selected for abstract review based on title relevance, and full text was chosen for review based on abstract relevance. Several related studies cited in initially reviewed literature were also chosen to compile more detailed information on specific molecules with the goal of at least two to three published articles for each protein.

Proteins that were cited to have only been found within the inner ear were included in this review, including some proteins that were later identified outside the inner ear. Information regarding their size, location, function, and clinical significance was recorded.Based on this literature search, eight proteins exclusive to the inner ear were identified including otolin-1, otoconin 90/95, prestin, otoancorin, otogelin, α-tectorin, β-tectorin, and cochlin. Proteins initially found to be exclusive to the inner ear though later identified outside of the inner ear included oncomodulin, otospiralin, and otoraplin. This literature review may serve as a focused guide for future research on proteins exclusive to the inner ear as potential biomarkers for diseases of the inner ear.

Oncomodulin: The Enigmatic Parvalbumin Protein.

EF-hand Ca2+-binding protein family members, α- and β-parvalbumins have been studied for decades. Yet, considerable information is lacking distinguishing functional differences between mammalian α-parvalbumin (PVALB) and oncomodulin (OCM), a branded β-parvalbumin. Herein, we provide an overview detailing the current body of work centered around OCM as an EF-Hand Ca2+-binding protein and describe potential mechanisms of OCM function within the inner ear and immune cells. Additionally, we posit that OCM is evolutionarily distinct from PVALB and most other β-parvalbumins. This review summarizes recent studies pertaining to the function of OCM and emphasizes OCM as a parvalbumin possessing a unique cell and tissue distribution, Ca2+ buffering capacity and phylogenetic origin.

On the Legacy of Genetically Altered Mouse Models to Explore Vestibular Function: Distribution of Vestibular Hair Cell Phenotypes in the Otoferlin-Null Mouse.

Early in his career, David Lim recognized the scientific impact of genetically anomalous mice exhibiting otoconia agenesis as models of drastically compromised vestibular function. While these studies focused on the mutant pallid mouse, contemporary genetic tools have produced other models with engineered functional modifications. Lim and colleagues foresaw the need to analyze vestibular epithelia from pallid mice to verify the absence of downstream consequences that might be secondary to the altered load represented by otoconial agenesis. More generally, however, such comparisons also contribute to an understanding of the susceptibility of labyrinthine sensory epithelia to more widespread cellular changes associated with what may appear as isolated modifications.Our laboratory utilizes a model of vestibular hypofunction produced through genetic alteration, the otoferlin-null mouse, which has been shown to exhibit severely compromised stimulus-evoked neurotransmitter release in type I hair cells of the utricular striola. The present study, reminiscent of early investigations of Lim and colleagues that explored the utility of a genetically altered mouse to explore its utility as a model of vestibular hypofunction, endeavored to compare the expression of the hair cell marker oncomodulin in vestibular epithelia from wild-type and otoferlin-null mice.

We found that levels of oncomodulin expression were much greater in type I than type II hair cells, though were similar across the 3 genotypes examined (ie, including heterozygotes).These findings support the notion that modifications resulting in a specific component of vestibular hypofunction are not accompanied by widespread morphologic and cellular changes in the vestibular sensory epithelia.

Sialix Research Lab

Oncomodulin (OCM) Antibody
20-abx100614	Abbexa	EUR 453.00 EUR 133.00 EUR 1302.00 EUR 620.00 EUR 342.00	100 ug 10 ug 1 mg 200 ug 50 ug

Mouse Oncomodulin (Ocm)
1-CSB-YP016264MO	Cusabio	EUR 586.00 EUR 299.00 EUR 2172.00 EUR 900.00 EUR 1442.00 EUR 382.00	100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Mouse Oncomodulin(Ocm) expressed in Yeast

Mouse Oncomodulin (Ocm)
1-CSB-EP016264MO	Cusabio	EUR 505.00 EUR 265.00 EUR 1827.00 EUR 766.00 EUR 1218.00 EUR 335.00	100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Mouse Oncomodulin(Ocm) expressed in E.coli

Recombinant Oncomodulin (OCM)
4-RPH506Hu01	Cloud-Clone	EUR 479.90 EUR 232.00 EUR 1524.64 EUR 574.88 EUR 1049.76 EUR 384.00 EUR 3661.60	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Human Oncomodulin expressed in: E.coli

Recombinant Oncomodulin (OCM)
4-RPH506Mu01	Cloud-Clone	EUR 494.24 EUR 235.00 EUR 1578.40 EUR 592.80 EUR 1085.60 EUR 394.00 EUR 3796.00	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Mouse Oncomodulin expressed in: E.coli

Recombinant Oncomodulin (OCM)
4-RPH506Ra01	Cloud-Clone	EUR 504.99 EUR 238.00 EUR 1618.72 EUR 606.24 EUR 1112.48 EUR 401.00 EUR 3896.80	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Rat Oncomodulin expressed in: E.coli

Human Oncomodulin (OCM) Protein
20-abx068381	Abbexa	EUR 676.00 EUR 272.00 EUR 2054.00 EUR 801.00 EUR 481.00	100 ug 10 ug 1 mg 200 ug 50 ug

Mouse Oncomodulin (OCM) Protein
20-abx068382	Abbexa	EUR 690.00 EUR 286.00 EUR 2124.00 EUR 815.00 EUR 495.00	100 ug 10 ug 1 mg 200 ug 50 ug

Rat Oncomodulin (OCM) Protein
20-abx068383	Abbexa	EUR 704.00 EUR 286.00 EUR 2179.00 EUR 843.00 EUR 509.00	100 ug 10 ug 1 mg 200 ug 50 ug

Recombinant Human Oncomodulin-1
7-05767	CHI Scientific	2µg	Ask for price

Recombinant Human Oncomodulin-1
7-05768	CHI Scientific	10µg	Ask for price

Recombinant Human Oncomodulin-1
7-05769	CHI Scientific	1mg	Ask for price

Oncomodulin-1 (OCM) Protein
20-abx262604	Abbexa	EUR 328.00 EUR 6397.00 EUR 230.00	10 ug 1 mg 2 µg

Oncomodulin 1 (Ocm) Antibody
20-abx318965	Abbexa	EUR 411.00 EUR 1845.00 EUR 599.00 EUR 182.00 EUR 300.00	100 ug 1 mg 200 ug 20 ug 50 ug

Oncomodulin-1 Recombinant Protein
91-225	ProSci	0.05 mg	EUR 684.5
Description: Oncomodulin-1 (OM) is a small, calcium-binding protein and a macrophage-derived growth factor, which can promote axon regeneration in retinal ganglion cells. Oncomodulin-1 is constitutively secreted by activated macrophages in the vitreous and retina in response to inflammatory conditions that promote optic nerve regeneration. Oncomodulin-1 binds RGCs with high affinity in vitro, but only when cAMP is pharmacologically elevated or if the membrane is permeabilized allowing Oncomodulin-1 access to the cytosolic compartment. Oncomodulin-1 is a member of the superfamily of calmodulin proteins and is a high-affinity calcium ion-binding protein and contains 2 EF-hand domains. OM is found in early embryonic cells in the placenta and also in tumors. It has some calmodulin-like activity with respect to enzyme activation and growth regulation.

Mouse Ocm/ Oncomodulin ELISA Kit
E1074Mo	Sunlong	1 Kit	EUR 632

Rat Ocm/ Oncomodulin ELISA Kit
E0710Ra	Sunlong	1 Kit	EUR 646

Oncomodulin 1 (Ocm) Antibody (HRP)
20-abx319295	Abbexa	EUR 411.00 EUR 1845.00 EUR 599.00 EUR 182.00 EUR 300.00	100 ug 1 mg 200 ug 20 ug 50 ug

Oncomodulin 1 (Ocm) Antibody (FITC)
20-abx319296	Abbexa	EUR 411.00 EUR 1845.00 EUR 599.00 EUR 182.00 EUR 300.00	100 ug 1 mg 200 ug 20 ug 50 ug

Oncomodulin 1 (Ocm) Antibody (Biotin)
20-abx319297	Abbexa	EUR 411.00 EUR 1845.00 EUR 599.00 EUR 182.00 EUR 300.00	100 ug 1 mg 200 ug 20 ug 50 ug

ELISA kit for Rat Oncomodulin
EK3207	SAB	96 tests	EUR 670
Description: Enzyme-linked immunosorbent assay kit for quantification of Rat Oncomodulin in samples from serum, plasma, tissue homogenates and other biological fluids.

Rat Ocm(Oncomodulin) ELISA Kit
ER0507	FN Test	96T	EUR 567.6
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Rattus;Sensitivity: 0.188 ng/ml

ELISA kit for Human Oncomodulin
EK5734	SAB	96 tests	EUR 553
Description: Enzyme-linked immunosorbent assay kit for quantification of Human Oncomodulin in samples from serum, plasma, tissue homogenates and other biological fluids.

Rat Oncomodulin(OCM) ELISA kit
CSB-EL016264RA-24T	Cusabio	1 plate of 24 wells	EUR 165
Description: Quantitativesandwich ELISA kit for measuring Rat Oncomodulin (OCM) in samples from serum, plasma, tissue homogenates, cell lysates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Rat Oncomodulin(OCM) ELISA kit
1-CSB-EL016264RA	Cusabio	EUR 804.00 EUR 5099.00 EUR 2704.00	1 plate of 96 wells 10 plates of 96 wells each 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Rat Oncomodulin(OCM) in samples from serum, plasma, tissue homogenates, cell lysates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Oncomodulin (OCM) Polyclonal Antibody (Mouse)
4-PAH506Mu01	Cloud-Clone	EUR 251.00 EUR 2576.00 EUR 640.00 EUR 316.00 EUR 215.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Oncomodulin (OCM)

Oncomodulin (OCM) Polyclonal Antibody (Rat)
4-PAH506Ra01	Cloud-Clone	EUR 259.00 EUR 2708.00 EUR 670.00 EUR 328.00 EUR 219.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Rat Oncomodulin (OCM)

Human Oncomodulin(OCM)ELISA Kit
QY-E04361	Qayee Biotechnology	96T	EUR 361

Rat Oncomodulin, Ocm ELISA KIT
ELI-04399r	Lifescience Market	96 Tests	EUR 886

Mouse Oncomodulin, Ocm ELISA KIT
ELI-04401m	Lifescience Market	96 Tests	EUR 865

Mouse Oncomodulin 1 (OCM) ELISA Kit
abx516437-96tests	Abbexa	96 tests	EUR 739

OCM Oncomodulin-1 Human Recombinant Protein
PROTP0CE72	BosterBio	Regular: 10ug	EUR 317
Description: The Recombinant Human Oncomodulin-1 produced in E.coli has a molecular mass of 13.21kDa containing 117 amino acid residues of the human Oncomodulin-1 and fused to a 9 a.a. His tag at N-terminus.

Human OCM/ Oncomodulin-1 ELISA Kit
E1820Hu	Sunlong	1 Kit	EUR 605

Rat Oncomodulin 1 (OCM) ELISA Kit
abx256484-96tests	Abbexa	96 tests	EUR 739

Human Oncomodulin 1 (OCM) ELISA Kit
abx250787-96tests	Abbexa	96 tests	EUR 668

ELISA kit for Human Oncomodulin-1
EK3206	SAB	96 tests	EUR 553
Description: Enzyme-linked immunosorbent assay kit for quantification of Human Oncomodulin-1 in samples from serum, plasma, tissue homogenates and other biological fluids.

Oncomodulin (OCM) Polyclonal Antibody (Human, Mouse)
4-PAH506Hu01	Cloud-Clone	EUR 247.00 EUR 2510.00 EUR 625.00 EUR 310.00 EUR 214.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human, Mouse Oncomodulin (OCM)

Oncomodulin (OCM) Polyclonal Antibody (Mouse), APC
4-PAH506Mu01-APC	Cloud-Clone	EUR 351.00 EUR 3365.00 EUR 935.00 EUR 449.00 EUR 222.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Oncomodulin (OCM). This antibody is labeled with APC.

Oncomodulin (OCM) Polyclonal Antibody (Mouse), Biotinylated
4-PAH506Mu01-Biotin	Cloud-Clone	EUR 316.00 EUR 2526.00 EUR 744.00 EUR 387.00 EUR 221.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Oncomodulin (OCM). This antibody is labeled with Biotin.

Oncomodulin (OCM) Polyclonal Antibody (Mouse), Cy3
4-PAH506Mu01-Cy3	Cloud-Clone	EUR 427.00 EUR 4445.00 EUR 1205.00 EUR 557.00 EUR 254.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Oncomodulin (OCM). This antibody is labeled with Cy3.

Oncomodulin (OCM) Polyclonal Antibody (Mouse), FITC
4-PAH506Mu01-FITC	Cloud-Clone	EUR 301.00 EUR 2712.00 EUR 768.00 EUR 379.00 EUR 197.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Oncomodulin (OCM). This antibody is labeled with FITC.

Oncomodulin (OCM) Polyclonal Antibody (Mouse), HRP
4-PAH506Mu01-HRP	Cloud-Clone	EUR 321.00 EUR 2933.00 EUR 827.00 EUR 405.00 EUR 209.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Oncomodulin (OCM). This antibody is labeled with HRP.

Oncomodulin (OCM) Polyclonal Antibody (Mouse), PE
4-PAH506Mu01-PE	Cloud-Clone	EUR 301.00 EUR 2712.00 EUR 768.00 EUR 379.00 EUR 197.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Mouse Oncomodulin (OCM). This antibody is labeled with PE.

Oncomodulin (OCM) Polyclonal Antibody (Rat), APC
4-PAH506Ra01-APC	Cloud-Clone	EUR 364.00 EUR 3545.00 EUR 980.00 EUR 467.00 EUR 227.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Rat Oncomodulin (OCM). This antibody is labeled with APC.

Oncomodulin Expression Reveals New Insights into the Cellular Organization of the Murine Utricle Striola.

Oncomodulin (OCM, aka β-parvalbumin) is an EF-hand calcium binding protein that is expressed in a restricted set of hair cells in the peristriolar region of the mammalian utricle. In the present study, we determined the topologic distribution of OCM among hair cell phenotypes to advance our understanding of the cellular organization of the striola and the relationship of these phenotypes with characteristics of tissue polarity. The distributions of OCM-positive (OCM+) hair cells were quantified in utricles.

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